The term 'fibroblast'often serves as a catch-all for a diverse array of mesenchymal cells,
including perivascular cells, stromal progenitor cells and bona fide fibroblasts. Although …

Activated fibroblasts in tumors, or cancer-associated fibroblasts (CAFs), have become a
popular research area over the past decade. As important players in many aspects of tumor …

Cell-based therapeutics are an emerging modality with the potential to treat many currently
intractable diseases through uniquely powerful modes of action. Despite notable recent …

Mesenchymal stem/stromal cells (MSCs) exist in almost all tissues and participate in tissue
regeneration and homeostasis. In-vitro-expanded MSCs are employed as therapeutics for …

Fibroblasts are diverse mesenchymal cells that participate in tissue homeostasis and
disease by producing complex extracellular matrix and creating signaling niches through …

Large bone defects resulting from fractures and disease are a major clinical challenge,
being often unable to heal spontaneously by the body's repair mechanisms. Lines of …

Osteoarthritis (OA) is a degenerative and chronic joint disease characterized by clinical
symptoms and distortion of joint tissues. It primarily damages joint cartilage, causing pain …

Extracellular vesicles (EVs) are cell-derived membrane structures enclosing proteins, lipids,
RNAs, metabolites, growth factors, and cytokines. EVs have emerged as essential …

Myofibroblasts are the construction workers of wound healing and repair damaged tissues
by producing and organizing collagen/extracellular matrix (ECM) into scar tissue. Scar tissue …

Due to the high prevalence and long incubation periods often without symptoms, the severe
acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected millions of individuals …