Parkinson's disease and dementia with Lewy bodies are currently defined by their clinical
features, with α-synuclein pathology as the gold standard to establish the definitive …

Compulsive behaviour, an apparently irrational perseveration in often maladaptive acts, is a
potential transdiagnostic symptom of several neuropsychiatric disorders, including …

Objective Randomized clinical trials have shown that aerobic exercise attenuates motor
symptom progression in Parkinson's disease, but the underlying neural mechanisms are …

Parkinson's disease prevalence is rapidly increasing in an aging global population. With this
increase comes exponentially rising social and economic costs, emphasizing the immediate …

Compulsion is a cardinal symptom of drug addiction (severe substance use disorder).
However, compulsion is observed in only a small proportion of individuals who repeatedly …

Dopamine is a critical modulator of both learning and motivation. This presents a problem:
how can target cells know whether increased dopamine is a signal to learn or to move? It is …

The mesolimbic hypothesis has been a central dogma of schizophrenia for decades,
positing that aberrant functioning of midbrain dopamine projections to limbic regions causes …

Physical exercise improves motor performance in individuals with Parkinson9s disease and
elevates mood in those with depression. Although underlying factors have not been …

Corticostriatal connections play a central role in develo** appropriate goal-directed
behaviors, including the motivation and cognition to develop appropriate actions to obtain a …

When people are forced to be isolated from each other, do they crave social interactions? To
address this question, we used functional magnetic resonance imaging to measure neural …