[HTML][HTML] Enantioselectivity in drug pharmacokinetics and toxicity: Pharmacological relevance and analytical methods

MM Coelho, C Fernandes, F Remião, ME Tiritan - Molecules, 2021 - mdpi.com
Enzymes, receptors, and other binding molecules in biological processes can recognize
enantiomers as different molecular entities, due to their different dissociation constants …

Enantioselective high-performance liquid chromatographic separations to study occurrence and fate of chiral pesticides in soil, water, and agricultural products

E Lucci, C Dal Bosco, L Antonelli, C Fanali… - … of Chromatography A, 2022 - Elsevier
As many as 40% of all plant protection products currently used contain chiral active
ingredients. Enantiomers of the same pesticide have identical physicochemical properties in …

Analysis, fate and toxicity of chiral non-steroidal anti-inflammatory drugs in wastewaters and the environment: a review

B Petrie, D Camacho-Muñoz - Environmental chemistry letters, 2021 - Springer
Non-steroidal anti-inflammatory drugs (NSAIDs) are found in the aquatic environment
globally. Such drugs including naproxen, ibuprofen and ketoprofen are chiral molecules …

[HTML][HTML] Deducing formation routes of oxylipins by quantitative multiple heart-cutting achiral-chiral 2D-LC-MS

N Kampschulte, R Kirchhoff, A Löwen… - Journal of Lipid …, 2024 - Elsevier
Several oxylipins are regulators of inflammation. They are formed by enzymes such as
lipoxygenases or cyclooxygenases, but also stereorandomly by autoxidation. Reversed …

Analysis of chiral drugs in environmental matrices: Current knowledge and trends in environmental, biodegradation and forensic fields

ARL Ribeiro, AS Maia, C Ribeiro, ME Tiritan - TrAC Trends in Analytical …, 2020 - Elsevier
The challenge to develop enantioselective analytical methods to quantify residues of chiral
drugs (CDs) in environmental matrices is an actual and imperative issue. It is well known …

Application of enantiomeric fractions in environmental forensics: Uncertainties and inconsistencies

E Sanganyado, Z Lu, W Liu - Environmental Research, 2020 - Elsevier
The assumption that only biological processes are enantioselective introduces challenges in
the reliability of enantioselective analysis as a tool for discriminating biotic and abiotic …

Study of the Chemical Composition and Biological Activity of the Essential Oil from Congona (Peperomia inaequalifolia Ruiz and Pav.)

E Valarezo, M Herrera-García, P Astudillo-Dávila… - Plants, 2023 - mdpi.com
The species Peperomia inaequalifolia, commonly known as congona, is a succulent
herbaceous plant belonging to the Piperaceae family, which is used for different purposes in …

Assessment of the Permeability of 3, 4-Methylenedioxypyrovalerone (MDPV) across the Caco-2 Monolayer for Estimation of Intestinal Absorption and …

AS Almeida, B Silva, F Remião… - International Journal of …, 2023 - mdpi.com
3, 4-Methylenedioxypyrovalerone (MDPV) is a widely studied synthetic cathinone
heterocycle mainly concerning its psychoactive effects. It is a chiral molecule and one of the …

Binding studies of synthetic cathinones to human serum albumin by high-performance affinity chromatography

AS Almeida, T Cardoso, S Cravo, ME Tiritan… - … of Chromatography B, 2023 - Elsevier
The binding affinity to human serum albumin (HSA) of a series of fourteen synthetic
cathinones, new psychoactive substances widely abused, was investigated by high …

Multi-milligram resolution and determination of absolute configuration of pentedrone and methylone enantiomers

B Silva, JA Pereira, S Cravo, AM Araújo… - … of Chromatography B, 2018 - Elsevier
The enantioresolution of pentedrone and methylone was carried out at a multi-milligram
scale by liquid chromatography on a Chiralpak AS® stationary phase. The excellent …