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[HTML][HTML] Enantioselectivity in drug pharmacokinetics and toxicity: Pharmacological relevance and analytical methods
MM Coelho, C Fernandes, F Remião, ME Tiritan - Molecules, 2021 - mdpi.com
Enzymes, receptors, and other binding molecules in biological processes can recognize
enantiomers as different molecular entities, due to their different dissociation constants …
enantiomers as different molecular entities, due to their different dissociation constants …
Enantioselective high-performance liquid chromatographic separations to study occurrence and fate of chiral pesticides in soil, water, and agricultural products
As many as 40% of all plant protection products currently used contain chiral active
ingredients. Enantiomers of the same pesticide have identical physicochemical properties in …
ingredients. Enantiomers of the same pesticide have identical physicochemical properties in …
Analysis, fate and toxicity of chiral non-steroidal anti-inflammatory drugs in wastewaters and the environment: a review
B Petrie, D Camacho-Muñoz - Environmental chemistry letters, 2021 - Springer
Non-steroidal anti-inflammatory drugs (NSAIDs) are found in the aquatic environment
globally. Such drugs including naproxen, ibuprofen and ketoprofen are chiral molecules …
globally. Such drugs including naproxen, ibuprofen and ketoprofen are chiral molecules …
[HTML][HTML] Deducing formation routes of oxylipins by quantitative multiple heart-cutting achiral-chiral 2D-LC-MS
N Kampschulte, R Kirchhoff, A Löwen… - Journal of Lipid …, 2024 - Elsevier
Several oxylipins are regulators of inflammation. They are formed by enzymes such as
lipoxygenases or cyclooxygenases, but also stereorandomly by autoxidation. Reversed …
lipoxygenases or cyclooxygenases, but also stereorandomly by autoxidation. Reversed …
Analysis of chiral drugs in environmental matrices: Current knowledge and trends in environmental, biodegradation and forensic fields
The challenge to develop enantioselective analytical methods to quantify residues of chiral
drugs (CDs) in environmental matrices is an actual and imperative issue. It is well known …
drugs (CDs) in environmental matrices is an actual and imperative issue. It is well known …
Application of enantiomeric fractions in environmental forensics: Uncertainties and inconsistencies
The assumption that only biological processes are enantioselective introduces challenges in
the reliability of enantioselective analysis as a tool for discriminating biotic and abiotic …
the reliability of enantioselective analysis as a tool for discriminating biotic and abiotic …
Study of the Chemical Composition and Biological Activity of the Essential Oil from Congona (Peperomia inaequalifolia Ruiz and Pav.)
E Valarezo, M Herrera-García, P Astudillo-Dávila… - Plants, 2023 - mdpi.com
The species Peperomia inaequalifolia, commonly known as congona, is a succulent
herbaceous plant belonging to the Piperaceae family, which is used for different purposes in …
herbaceous plant belonging to the Piperaceae family, which is used for different purposes in …
Assessment of the Permeability of 3, 4-Methylenedioxypyrovalerone (MDPV) across the Caco-2 Monolayer for Estimation of Intestinal Absorption and …
AS Almeida, B Silva, F Remião… - International Journal of …, 2023 - mdpi.com
3, 4-Methylenedioxypyrovalerone (MDPV) is a widely studied synthetic cathinone
heterocycle mainly concerning its psychoactive effects. It is a chiral molecule and one of the …
heterocycle mainly concerning its psychoactive effects. It is a chiral molecule and one of the …
Binding studies of synthetic cathinones to human serum albumin by high-performance affinity chromatography
The binding affinity to human serum albumin (HSA) of a series of fourteen synthetic
cathinones, new psychoactive substances widely abused, was investigated by high …
cathinones, new psychoactive substances widely abused, was investigated by high …
Multi-milligram resolution and determination of absolute configuration of pentedrone and methylone enantiomers
B Silva, JA Pereira, S Cravo, AM Araújo… - … of Chromatography B, 2018 - Elsevier
The enantioresolution of pentedrone and methylone was carried out at a multi-milligram
scale by liquid chromatography on a Chiralpak AS® stationary phase. The excellent …
scale by liquid chromatography on a Chiralpak AS® stationary phase. The excellent …