Interrogating amyloid aggregates using fluorescent probes

A Aliyan, NP Cook, AA Martí - Chemical reviews, 2019 - ACS Publications
Amyloids are a broad class of proteins and peptides that can misfold and assemble into long
unbranched fibrils with a cross-β conformation. These misfolding and aggregation events …

Water-soluble conjugated polymers for imaging, diagnosis, and therapy

C Zhu, L Liu, Q Yang, F Lv, S Wang - Chemical reviews, 2012 - ACS Publications
Conjugated polymers (CPs) are characterized by a delocalized electronic structure that
exhibits efficient coupling between optoelectronic segments. Excitons can be efficiently …

Conjugated polymers for assessing and controlling biological functions

E Zeglio, AL Rutz, TE Winkler, GG Malliaras… - Advanced …, 2019 - Wiley Online Library
The field of organic bioelectronics is advancing rapidly in the development of materials and
devices to precisely monitor and control biological signals. Electronics and biology can …

[CARTE][B] Handbook of conducting polymers

TA Skotheim - 1997 - books.google.com
Discussing theory and transport, synthesis, processing, properties, and applications, this
second edition of a standard resource covers advances in the field of electrically conducting …

Chemical sensors based on amplifying fluorescent conjugated polymers

SW Thomas, GD Joly, TM Swager - Chemical reviews, 2007 - ACS Publications
The field of chemical sensing is becoming ever more dependent upon novel materials.
Polymers, crystals, glasses, particles, and nanostructures have made a profound impact and …

Binding mode of Thioflavin T and other molecular probes in the context of amyloid fibrils—current status

M Groenning - Journal of chemical biology, 2010 - Springer
Because understanding amyloid fibrillation in molecular detail is essential for development
of strategies to control amyloid formation and overcome neurodegenerative disorders …

Prions: protein aggregation and infectious diseases

A Aguzzi, AM Calella - Physiological reviews, 2009 - journals.physiology.org
Transmissible spongiform encephalopathies (TSEs) are inevitably lethal neurodegenerative
diseases that affect humans and a large variety of animals. The infectious agent responsible …

Small molecule inhibitors of aggregation indicate that amyloid β oligomerization and fibrillization pathways are independent and distinct

M Necula, R Kayed, S Milton, CG Glabe - Journal of Biological Chemistry, 2007 - jbc.org
Alzheimer disease is characterized by the abnormal aggregation of amyloid β peptide into
extracellular fibrillar deposits known as amyloid plaques. Soluble oligomers have been …

Novel Pentameric Thiophene Derivatives for in Vitro and in Vivo Optical Imaging of a Plethora of Protein Aggregates in Cerebral Amyloidoses

A Åslund, CJ Sigurdson, T Klingstedt… - ACS chemical …, 2009 - ACS Publications
Molecular probes for selective identification of protein aggregates are important to advance
our understanding of the molecular pathogenesis underlying cerebral amyloidoses. Here we …

Amyloid fibril polymorphism: a challenge for molecular imaging and therapy

M Fändrich, S Nyström, KPR Nilsson… - Journal of Internal …, 2018 - Wiley Online Library
The accumulation of misfolded proteins (MP s), both unique and common, for different
diseases is central for many chronic degenerative diseases. In certain patients, MP …