Interrogating amyloid aggregates using fluorescent probes
Amyloids are a broad class of proteins and peptides that can misfold and assemble into long
unbranched fibrils with a cross-β conformation. These misfolding and aggregation events …
unbranched fibrils with a cross-β conformation. These misfolding and aggregation events …
Water-soluble conjugated polymers for imaging, diagnosis, and therapy
Conjugated polymers (CPs) are characterized by a delocalized electronic structure that
exhibits efficient coupling between optoelectronic segments. Excitons can be efficiently …
exhibits efficient coupling between optoelectronic segments. Excitons can be efficiently …
Conjugated polymers for assessing and controlling biological functions
The field of organic bioelectronics is advancing rapidly in the development of materials and
devices to precisely monitor and control biological signals. Electronics and biology can …
devices to precisely monitor and control biological signals. Electronics and biology can …
[CARTE][B] Handbook of conducting polymers
TA Skotheim - 1997 - books.google.com
Discussing theory and transport, synthesis, processing, properties, and applications, this
second edition of a standard resource covers advances in the field of electrically conducting …
second edition of a standard resource covers advances in the field of electrically conducting …
Chemical sensors based on amplifying fluorescent conjugated polymers
The field of chemical sensing is becoming ever more dependent upon novel materials.
Polymers, crystals, glasses, particles, and nanostructures have made a profound impact and …
Polymers, crystals, glasses, particles, and nanostructures have made a profound impact and …
Binding mode of Thioflavin T and other molecular probes in the context of amyloid fibrils—current status
M Groenning - Journal of chemical biology, 2010 - Springer
Because understanding amyloid fibrillation in molecular detail is essential for development
of strategies to control amyloid formation and overcome neurodegenerative disorders …
of strategies to control amyloid formation and overcome neurodegenerative disorders …
Prions: protein aggregation and infectious diseases
A Aguzzi, AM Calella - Physiological reviews, 2009 - journals.physiology.org
Transmissible spongiform encephalopathies (TSEs) are inevitably lethal neurodegenerative
diseases that affect humans and a large variety of animals. The infectious agent responsible …
diseases that affect humans and a large variety of animals. The infectious agent responsible …
Small molecule inhibitors of aggregation indicate that amyloid β oligomerization and fibrillization pathways are independent and distinct
Alzheimer disease is characterized by the abnormal aggregation of amyloid β peptide into
extracellular fibrillar deposits known as amyloid plaques. Soluble oligomers have been …
extracellular fibrillar deposits known as amyloid plaques. Soluble oligomers have been …
Novel Pentameric Thiophene Derivatives for in Vitro and in Vivo Optical Imaging of a Plethora of Protein Aggregates in Cerebral Amyloidoses
Molecular probes for selective identification of protein aggregates are important to advance
our understanding of the molecular pathogenesis underlying cerebral amyloidoses. Here we …
our understanding of the molecular pathogenesis underlying cerebral amyloidoses. Here we …
Amyloid fibril polymorphism: a challenge for molecular imaging and therapy
M Fändrich, S Nyström, KPR Nilsson… - Journal of Internal …, 2018 - Wiley Online Library
The accumulation of misfolded proteins (MP s), both unique and common, for different
diseases is central for many chronic degenerative diseases. In certain patients, MP …
diseases is central for many chronic degenerative diseases. In certain patients, MP …