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Molecular mechanisms of brain water transport
N MacAulay - Nature Reviews Neuroscience, 2021 - nature.com
Our brains consist of 80% water, which is continuously shifted between different
compartments and cell types during physiological and pathophysiological processes …
compartments and cell types during physiological and pathophysiological processes …
The glymphatic system: a beginner's guide
NA Jessen, ASF Munk, I Lundgaard… - Neurochemical …, 2015 - Springer
The glymphatic system is a recently discovered macroscopic waste clearance system that
utilizes a unique system of perivascular tunnels, formed by astroglial cells, to promote …
utilizes a unique system of perivascular tunnels, formed by astroglial cells, to promote …
Cerebrospinal fluid secretion by the choroid plexus
The choroid plexus epithelium is a cuboidal cell monolayer, which produces the majority of
the cerebrospinal fluid. The concerted action of a variety of integral membrane proteins …
the cerebrospinal fluid. The concerted action of a variety of integral membrane proteins …
The SLC4 family of bicarbonate (HCO3-) transporters
The SLC4 family consists of 10 genes (SLC4A1–5; SLC4A7–11). All encode integral
membrane proteins with very similar hydropathy plots—consistent with 10–14 …
membrane proteins with very similar hydropathy plots—consistent with 10–14 …
Transport across the choroid plexus epithelium
The choroid plexus epithelium is a secretory epithelium par excellence. However, this is
perhaps not the most prominent reason for the massive interest in this modest-sized tissue …
perhaps not the most prominent reason for the massive interest in this modest-sized tissue …
Cerebrospinal fluid production by the choroid plexus: a century of barrier research revisited
Cerebrospinal fluid (CSF) envelops the brain and fills the central ventricles. This fluid is
continuously replenished by net fluid extraction from the vasculature by the secretory action …
continuously replenished by net fluid extraction from the vasculature by the secretory action …
Disrupting hypoxia-induced bicarbonate transport acidifies tumor cells and suppresses tumor growth
A McIntyre, A Hulikova, I Ledaki, C Snell… - Cancer …, 2016 - aacrjournals.org
Tumor hypoxia is associated clinically with therapeutic resistance and poor patient
outcomes. One feature of tumor hypoxia is activated expression of carbonic anhydrase IX …
outcomes. One feature of tumor hypoxia is activated expression of carbonic anhydrase IX …
Physiological and pathological impact of AQP1 knockout in mice
Y Hua, X Ying, Y Qian, H Liu, Y Lan, A **e… - Bioscience …, 2019 - portlandpress.com
Abstract Aquaporin 1 (AQP1) is a glycoprotein responsible for water passive transport
quickly across biological membrane. Here, we reviewed the structural and functional …
quickly across biological membrane. Here, we reviewed the structural and functional …
Cerebrospinal fluid pH regulation
The cerebrospinal fluid (CSF) fills the brain ventricles and the subarachnoid space
surrounding the brain and spinal cord. The fluid compartment of the brain ventricles …
surrounding the brain and spinal cord. The fluid compartment of the brain ventricles …
Targeting choroid plexus epithelium as a novel therapeutic strategy for hydrocephalus
Y Yang, J He, Y Wang, C Wang, C Tan, J Liao… - Journal of …, 2022 - Springer
The choroid plexus is a tissue located in the lateral ventricles of the brain and is composed
mainly of choroid plexus epithelium cells. The main function is currently thought to be the …
mainly of choroid plexus epithelium cells. The main function is currently thought to be the …