Molecular mechanisms of brain water transport

N MacAulay - Nature Reviews Neuroscience, 2021 - nature.com
Our brains consist of 80% water, which is continuously shifted between different
compartments and cell types during physiological and pathophysiological processes …

The glymphatic system: a beginner's guide

NA Jessen, ASF Munk, I Lundgaard… - Neurochemical …, 2015 - Springer
The glymphatic system is a recently discovered macroscopic waste clearance system that
utilizes a unique system of perivascular tunnels, formed by astroglial cells, to promote …

Cerebrospinal fluid secretion by the choroid plexus

HH Damkier, PD Brown… - Physiological reviews, 2013 - journals.physiology.org
The choroid plexus epithelium is a cuboidal cell monolayer, which produces the majority of
the cerebrospinal fluid. The concerted action of a variety of integral membrane proteins …

The SLC4 family of bicarbonate (HCO3-) transporters

MF Romero, AP Chen, MD Parker, WF Boron - Molecular aspects of …, 2013 - Elsevier
The SLC4 family consists of 10 genes (SLC4A1–5; SLC4A7–11). All encode integral
membrane proteins with very similar hydropathy plots—consistent with 10–14 …

Transport across the choroid plexus epithelium

J Praetorius, HH Damkier - American Journal of Physiology …, 2017 - journals.physiology.org
The choroid plexus epithelium is a secretory epithelium par excellence. However, this is
perhaps not the most prominent reason for the massive interest in this modest-sized tissue …

Cerebrospinal fluid production by the choroid plexus: a century of barrier research revisited

N MacAulay, RF Keep, T Zeuthen - Fluids and Barriers of the CNS, 2022 - Springer
Cerebrospinal fluid (CSF) envelops the brain and fills the central ventricles. This fluid is
continuously replenished by net fluid extraction from the vasculature by the secretory action …

Disrupting hypoxia-induced bicarbonate transport acidifies tumor cells and suppresses tumor growth

A McIntyre, A Hulikova, I Ledaki, C Snell… - Cancer …, 2016 - aacrjournals.org
Tumor hypoxia is associated clinically with therapeutic resistance and poor patient
outcomes. One feature of tumor hypoxia is activated expression of carbonic anhydrase IX …

Physiological and pathological impact of AQP1 knockout in mice

Y Hua, X Ying, Y Qian, H Liu, Y Lan, A **e… - Bioscience …, 2019 - portlandpress.com
Abstract Aquaporin 1 (AQP1) is a glycoprotein responsible for water passive transport
quickly across biological membrane. Here, we reviewed the structural and functional …

Cerebrospinal fluid pH regulation

HH Damkier, J Praetorius - Pflügers Archiv-European Journal of …, 2024 - Springer
The cerebrospinal fluid (CSF) fills the brain ventricles and the subarachnoid space
surrounding the brain and spinal cord. The fluid compartment of the brain ventricles …

Targeting choroid plexus epithelium as a novel therapeutic strategy for hydrocephalus

Y Yang, J He, Y Wang, C Wang, C Tan, J Liao… - Journal of …, 2022 - Springer
The choroid plexus is a tissue located in the lateral ventricles of the brain and is composed
mainly of choroid plexus epithelium cells. The main function is currently thought to be the …