Dysregulated cellular proliferation represents a hallmark feature across all cancers. Aberrant
activation of the cyclin-dependent kinase 4 and 6 (CDK4/6) pathway, independent of …

Skeletal metastases are frequent complications of many cancers, causing bone
complications (fractures, bone pain, disability) that negatively affect the patient's quality of …

Highlights•The clinical course of advanced cancer for many patients with bone metastases
can be transformed through optimum multidisciplinary management.•Bone-targeted agents …

Osteoporosis is a bone disorder with remarkable changes in bone biologic material and
consequent bone structural distraction, affecting millions of people around the world from …

Patients with primary and bone metastatic breast cancer have significantly reduced survival
and life quality. Due to the poor drug delivery efficiency of anti-metastasis therapy and the …

Skeletal complications caused by osteoporosis or bone metastases are associated with
considerable pain, increased mortality, and reduced quality of life. Furthermore, such events …

The skeletal system is the third most common site for cancer metastases, surpassed only by
the lungs and liver. Many tumors, especially those of the breast, prostate, lungs, and …

Bone metastasis is an incurable complication of breast cancer. In advanced stages, patients
with estrogen-positive tumors experience a significantly higher incidence of bone metastasis …

Metastasis has been considered as the terminal step of tumor progression. However, recent
genomic studies suggest that many metastases are initiated by further spread of other …

Medication-related osteonecrosis of the jaw (MRONJ) is primarily an adverse side effect of
denosumab or bisphosphonates (particularly when used at high doses to prevent skeletal …