PPARs as metabolic regulators in the liver: lessons from liver-specific PPAR-null mice
Y Wang, T Nakajima, FJ Gonzalez… - International journal of …, 2020 - mdpi.com
Peroxisome proliferator-activated receptor (PPAR) α, β/δ, and γ modulate lipid homeostasis.
PPARα regulates lipid metabolism in the liver, the organ that largely controls whole-body …
PPARα regulates lipid metabolism in the liver, the organ that largely controls whole-body …
The mechanisms of action of PPARs
J Berger, DE Moller - Annual review of medicine, 2002 - annualreviews.org
▪ Abstract The peroxisome proliferator-activated receptors (PPARs) are a group of three
nuclear receptor isoforms, PPARγ, PPARα, and PPARδ, encoded by different genes. PPARs …
nuclear receptor isoforms, PPARγ, PPARα, and PPARδ, encoded by different genes. PPARs …
Nuclear receptors and lipid physiology: opening the X-files
Cholesterol, fatty acids, fat-soluble vitamins, and other lipids present in our diets are not only
nutritionally important but serve as precursors for ligands that bind to receptors in the …
nutritionally important but serve as precursors for ligands that bind to receptors in the …
Role of PPAR receptor in different diseases and their ligands: Physiological importance and clinical implications
The peroxisome proliferator-activated receptors (PPAR-α, PPAR-β/δ, and PPAR-γ) are
members of the nuclear receptor super-family, acting as ligand-inducible transcription …
members of the nuclear receptor super-family, acting as ligand-inducible transcription …
Obesity I: Overview and molecular and biochemical mechanisms
Obesity is a chronic, relapsing condition characterized by excess body fat. Its prevalence
has increased globally since the 1970s, and the number of obese and overweight people is …
has increased globally since the 1970s, and the number of obese and overweight people is …
Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs
Highly potent, but poorly water-soluble, drug candidates are common outcomes of
contemporary drug discovery programmes and present a number of challenges to drug …
contemporary drug discovery programmes and present a number of challenges to drug …
PPARs and the complex journey to obesity
RM Evans, GD Barish, YX Wang - Nature medicine, 2004 - nature.com
Obesity and the related disorders of dyslipidemia and diabetes (components of syndrome X)
have become global health epidemics. Over the past decade, the elucidation of key …
have become global health epidemics. Over the past decade, the elucidation of key …
PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD
Obesity is a worldwide epidemic that predisposes individuals to cardiometabolic
complications, such as type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease …
complications, such as type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease …
Mammalian ABC transporters in health and disease
P Borst, RO Elferink - Annual review of biochemistry, 2002 - annualreviews.org
▪ Abstract The ATP-binding cassette (ABC) transporters are a family of large proteins in
membranes and are able to transport a variety of compounds through membranes against …
membranes and are able to transport a variety of compounds through membranes against …
[HTML][HTML] Roles of the peroxisome proliferator-activated receptors (PPARs) in the pathogenesis of nonalcoholic fatty liver disease (NAFLD)
YY Qiu, J Zhang, FY Zeng, YZ Zhu - Pharmacological Research, 2023 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of disease phenotypes
which start with simple steatosis and lipid accumulation in the hepatocytes-a typical …
which start with simple steatosis and lipid accumulation in the hepatocytes-a typical …