Endocytosis in cancer and cancer therapy
Endocytosis is a complex process whereby cell surface proteins, lipids and fluid from the
extracellular environment are packaged, sorted and internalized into cells. Endocytosis is …
extracellular environment are packaged, sorted and internalized into cells. Endocytosis is …
Immune and non-immune functions of adipose tissue leukocytes
Adipose tissue is a complex dynamic organ with whole-body immunometabolic influence.
Much of the work into understanding the role of immune cells in adipose tissue has been in …
Much of the work into understanding the role of immune cells in adipose tissue has been in …
Molecular mechanism of fast endophilin-mediated endocytosis
A Casamento, E Boucrot - Biochemical Journal, 2020 - portlandpress.com
Endocytosis mediates the cellular uptake of micronutrients and cell surface proteins. Clathrin-
mediated endocytosis (CME) is the housekee** pathway in resting cells but additional …
mediated endocytosis (CME) is the housekee** pathway in resting cells but additional …
Unconventional endocytic mechanisms
Endocytosis mediates the uptake of extracellular proteins, micronutrients and
transmembrane cell surface proteins. Importantly, many viruses, toxins and bacteria hijack …
transmembrane cell surface proteins. Importantly, many viruses, toxins and bacteria hijack …
Mechanisms of carrier formation during clathrin-independent endocytosis
Clathrin-independent endocytosis (CIE) mediates the cellular uptake of many extracellular
ligands, receptors, and pathogens, including several life-threatening bacterial toxins and …
ligands, receptors, and pathogens, including several life-threatening bacterial toxins and …
The EGFR odyssey–from activation to destruction in space and time
When cell surface receptors engage their cognate ligands in the extracellular space, they
become competent to transmit potent signals to the inside of the cell, thereby instigating …
become competent to transmit potent signals to the inside of the cell, thereby instigating …
Vasculature-associated fat macrophages readily adapt to inflammatory and metabolic challenges
Tissue-resident macrophages are the most abundant immune cell population in healthy
adipose tissue. Adipose tissue macrophages (ATMs) change during metabolic stress and …
adipose tissue. Adipose tissue macrophages (ATMs) change during metabolic stress and …
ESCRT-dependent cargo sorting at multivesicular endosomes
The endosomal sorting complex required for transport (ESCRT) machinery is composed of
five multi-subunit protein complexes, which act cooperatively at specialized endosomes to …
five multi-subunit protein complexes, which act cooperatively at specialized endosomes to …
Acyl chain asymmetry and polyunsaturation of brain phospholipids facilitate membrane vesiculation without leakage
Phospholipid membranes form cellular barriers but need to be flexible enough to divide by
fission. Phospholipids generally contain a saturated fatty acid (FA) at position sn1 whereas …
fission. Phospholipids generally contain a saturated fatty acid (FA) at position sn1 whereas …
[HTML][HTML] Diversity of the Gβγ complexes defines spatial and temporal bias of GPCR signaling
The signal transduction by G-protein-coupled receptors (GPCRs) is mediated by
heterotrimeric G proteins composed from one of the 16 Gα subunits and the inseparable Gβγ …
heterotrimeric G proteins composed from one of the 16 Gα subunits and the inseparable Gβγ …