Induced pluripotent stem cells (iPSCs): molecular mechanisms of induction and applications
The induced pluripotent stem cell (iPSC) technology has transformed in vitro research and
holds great promise to advance regenerative medicine. iPSCs have the capacity for an …
holds great promise to advance regenerative medicine. iPSCs have the capacity for an …
White matter injury across neurodegenerative disease
Abstract Oligodendrocytes (OLs), the myelin-generating cells of the central nervous system
(CNS), are active players in sha** neuronal circuitry and function. It has become …
(CNS), are active players in sha** neuronal circuitry and function. It has become …
APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition
Summary The Christchurch mutation (R136S) on the APOE3 (E3S/S) gene is associated
with low tau pathology and slowdown of cognitive decline despite the causal PSEN1 …
with low tau pathology and slowdown of cognitive decline despite the causal PSEN1 …
Astrocyte-derived clusterin disrupts glial physiology to obstruct remyelination in mouse models of demyelinating diseases
C Chen, Y Shu, C Yan, H Li, Z Huang, SS Shen… - Nature …, 2024 - nature.com
Multiple sclerosis (MS) is a debilitating demyelinating disease characterized by
remyelination failure attributed to inadequate oligodendrocyte precursor cells (OPCs) …
remyelination failure attributed to inadequate oligodendrocyte precursor cells (OPCs) …
Develo** a human iPSC-derived three-dimensional myelin spheroid platform for modeling myelin diseases
Myelin defects cause a collection of myelin disorders in the brain. The lack of human models
has limited us from better understanding pathological mechanisms of myelin diseases …
has limited us from better understanding pathological mechanisms of myelin diseases …
Microglial APOE3 Christchurch protects neurons from Tau pathology in a human iPSC-based model of Alzheimer's disease
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder characterized by
extracellular amyloid plaques and neuronal Tau tangles. A recent study found that the …
extracellular amyloid plaques and neuronal Tau tangles. A recent study found that the …
The current situation and development prospect of whole-genome screening
C Yang, Y Lei, T Ren, M Yao - International Journal of Molecular Sciences, 2024 - mdpi.com
High-throughput genetic screening is useful for discovering critical genes or gene
sequences that trigger specific cell functions and/or phenotypes. Loss-of-function genetic …
sequences that trigger specific cell functions and/or phenotypes. Loss-of-function genetic …
Pathologic TDP‐43 downregulates myelin gene expression in the monkey brain
L Zhu, D Bai, X Wang, K Ou, B Li, Q Jia, Z Tan… - Brain …, 2024 - Wiley Online Library
Growing evidence indicates that non‐neuronal oligodendrocyte plays an important role in
Amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. In patient's …
Amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. In patient's …
Myelin organoids for the study of Alzheimer's disease
Alzheimer's disease (AD) remains a leading cause of dementia and poses a heavy burden
on aging populations worldwide (Long and Holtzman, 2019). Amyloid-targeting antibodies …
on aging populations worldwide (Long and Holtzman, 2019). Amyloid-targeting antibodies …
[HTML][HTML] Comorbidity genes of Alzheimer's disease and type 2 diabetes associated with memory and cognitive function
SB Cho - International Journal of Molecular Sciences, 2024 - mdpi.com
Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) are comorbidities that result
from the sharing of common genes. The molecular background of comorbidities can provide …
from the sharing of common genes. The molecular background of comorbidities can provide …