Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases
Allergic inflammation is accompanied by the coordinated expression of a myriad of genes
and proteins that initiate, sustain, and propagate immune responses and tissue remodeling …
and proteins that initiate, sustain, and propagate immune responses and tissue remodeling …
miR-223: a key regulator in the innate immune response in asthma and COPD
Asthma and Chronic Obstructive Pulmonary Disease (COPD) are chronic obstructive
respiratory diseases characterized by airway obstruction, inflammation, and remodeling …
respiratory diseases characterized by airway obstruction, inflammation, and remodeling …
Altered microRNA profiles in bronchoalveolar lavage fluid exosomes in asthmatic patients
B Levänen, NR Bhakta, PT Paredes, R Barbeau… - Journal of Allergy and …, 2013 - Elsevier
BACKGROUND: Asthma is characterized by increased airway narrowing in response to
nonspecific stimuli. The disorder is influenced by both environmental and genetic factors …
nonspecific stimuli. The disorder is influenced by both environmental and genetic factors …
IL-4/IL-13-dependent and independent expression of miR-124 and its contribution to M2 phenotype of monocytic cells in normal conditions and during allergic …
Monocytic cells exhibit a high level of heterogeneity and have two distinct modes of their
activation: 1) classical M1 path associated with inflammation and tissue damage, and 2) …
activation: 1) classical M1 path associated with inflammation and tissue damage, and 2) …
Treatment of allergic asthma: modulation of Th2 cells and their responses
Atopic asthma is a chronic inflammatory pulmonary disease characterised by recurrent
episodes of wheezy, laboured breathing with an underlying Th2 cell-mediated inflammatory …
episodes of wheezy, laboured breathing with an underlying Th2 cell-mediated inflammatory …
Role of microRNAs in lung development and pulmonary diseases
MicroRNAs (miRNAs) are a class of small noncoding RNA which exert post-transcriptional
gene regulation activity by targeting messenger RNAs. miRNAs have been found to be …
gene regulation activity by targeting messenger RNAs. miRNAs have been found to be …
A network of sputum microRNAs is associated with neutrophilic airway inflammation in asthma
Rationale: MicroRNAs are potent regulators of biologic systems that are critical to tissue
homeostasis. Individual microRNAs have been identified in airway samples. However, a …
homeostasis. Individual microRNAs have been identified in airway samples. However, a …
The role of microRNAs in chronic respiratory disease: recent insights
Chronic respiratory diseases encompass a group of diverse conditions affecting the airways,
which all impair lung function over time. They include cystic fibrosis (CF), idiopathic …
which all impair lung function over time. They include cystic fibrosis (CF), idiopathic …
MicroRNA regulation of allergic inflammation and asthma
Highlights•miRNAs regulate allergic inflammation and allergic responses.•miRNAs act
coordinately through target gene networks.•miRNAs impact diverse cellular functions in type …
coordinately through target gene networks.•miRNAs impact diverse cellular functions in type …
Circulating microRNAs and prediction of asthma exacerbation in childhood asthma
Background Circulating microRNAs have shown promise as non-invasive biomarkers and
predictors of disease activity. Prior asthma studies using clinical, biochemical and genomic …
predictors of disease activity. Prior asthma studies using clinical, biochemical and genomic …