The mitochondrial permeability transition (mPT) describes a Ca2+-dependent and
cyclophilin D (CypD)-facilitated increase of inner mitochondrial membrane permeability that …

Age is the main risk factor for a number of human diseases, including neurodegenerative
disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral …

While the liver demonstrates remarkable resilience during aging, there is growing evidence
that it undergoes all the cellular hallmarks of aging, which increases the risk of liver and …

Selective autophagy of mitochondria, known as mitophagy, is an important mitochondrial
quality control mechanism that eliminates damaged mitochondria. Mitophagy also mediates …

Abstract Beckman, Kenneth B., and Bruce N. Ames. The Free Radical Theory of Aging
Matures. Physiol. Rev. 78: 547–581, 1998.—The free radical theory of aging, conceived in …

Nuclear lamin B1 (LB1) is a major structural component of the nucleus that appears to be
involved in the regulation of many nuclear functions. The results of this study demonstrate …

Postoperative cognitive dysfunction (POCD) is defined by cognitive impairment determined
by neuropsychological tests from before to after surgery. Several mechanisms have been …

Sirtuins are a highly conserved family of proteins whose activity can prolong the lifespan of
model organisms such as yeast, worms and flies. Mammals contain seven sirtuins (SIRT1 …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

Recent studies of postmortem brains from Alzheimer's disease (AD) patients and transgenic
mouse models of AD suggest that oxidative damage, induced by amyloid β (Aβ), is …