AMP-activated protein kinase (AMPK) has a major role in the modulation of energy balance.
AMPK is activated in conditions of low energy, increasing energy production and reducing …

Metabolic disorders, particularly aberrations in lipid homeostasis, such as obesity, type 2
diabetes mellitus, and hypertriglyceridemia often manifest together as the metabolic …

In Parkinson's disease (PD), α-synuclein (αS) pathologically impacts the brain, a highly lipid-
rich organ. We investigated how alterations in αS or lipid/fatty acid homeostasis affect each …

The suprachiasmatic nucleus (SCN) in the mammalian hypothalamus functions as an
endogenous pacemaker that generates and maintains circadian rhythms throughout the …

Glioblastoma multiforme (GBM) is the most common and lethal primary malignant brain
tumor in adults. Despite the multimodal standard treatments for GBM, the median survival is …

Fatty acid metabolism, including β-oxidation (βOX), plays an important role in human
physiology and pathology. βOX is an essential process in the energy metabolism of most …

Astrocyte-mediated inflammation is associated with degenerative pathologies such as
Alzheimer's and Parkinson's diseases and multiple sclerosis. The acute inflammation and …

Overconsumption of dietary fat is increasingly linked with motivational and emotional
impairments. Human and animal studies demonstrate associations between obesity and …

Fibrosis is an exaggerated form of tissue repair that occurs with serious damage or repetitive
injury and ultimately leads to organ failure due to the excessive scarring. Increased calcium …

Migraine is a common headache with a large negative impact on health. Several
endogenous and exogenous factors can influence the severity and frequency of migraine …