Synthesis of Fluorinated Nucleosides/Nucleotides and Their Antiviral Properties

Y Kothapalli, RA Jones, CK Chu, US Singh - Molecules, 2024 - mdpi.com
The FDA has approved several drugs based on the fluorinated nucleoside pharmacophore,
and numerous drugs are currently in clinical trials. Fluorine-containing nucleos (t) ides offer …

European College of Equine Internal Medicine consensus statement on equine flaviviridae infections in Europe

JMV Cavalleri, O Korbacska‐Kutasi… - Journal of veterinary …, 2022 - Wiley Online Library
Horses and other equids can be infected with several viruses of the family Flaviviridae,
belonging to the genus Flavivirus and Hepacivirus. This consensus statement focuses on …

[HTML][HTML] Structural homology-based drug repurposing approach for targeting NSP12 SARS-CoV-2

A Aljuaid, A Salam, M Almehmadi, S Baammi… - Molecules, 2022 - mdpi.com
The severe acute respiratory syndrome coronavirus 2, also known as SARS-CoV-2, is the
causative agent of the COVID-19 global pandemic. SARS-CoV-2 has a highly conserved …

COVID-19: CADD to the rescue

AT Onawole, KO Sulaiman, TU Kolapo, FO Akinde… - Virus Research, 2020 - Elsevier
The recent outbreak of the deadly COVID-19 disease, being caused by the novel
coronavirus (SARS-CoV-2), has put the world on red alert as it keeps spreading and …

Regulation of NS5B Polymerase Activity of Hepatitis C Virus by Target Specific Phytotherapeutics: An In-Silico Molecular Dynamics Approach

S Dhanasekaran, PP Selvadoss… - Cell Biochemistry and …, 2024 - Springer
Chronic hepatitis caused by the hepatitis C virus (HCV) is closely linked with the
advancement of liver disease. The research hypothesis suggests that the NS5B enzyme …

StackHCV: A web-based integrative machine-learning framework for large-scale identification of hepatitis C virus NS5B inhibitors

AA Malik, W Chotpatiwetchkul… - Journal of Computer …, 2021 - Springer
Fast and accurate identification of inhibitors with potency against HCV NS5B polymerase is
currently a challenging task. As conventional experimental methods is the gold standard …

[ΒΙΒΛΙΟ][B] Infectious diseases of the horse: diagnosis, pathology, management, and public health

JH van der Kolk, EJBV Kroeze - 2022 - taylorfrancis.com
A clinician and a pathologist collaborate to create a comprehensive yet practical book about
established infectious diseases of horses, categorised according to the different pathogens …

HCVpred: A web server for predicting the bioactivity of hepatitis C virus NS5B inhibitors

AA Malik, C Phanus‐umporn… - Journal of …, 2020 - Wiley Online Library
Hepatitis C virus (HCV) is one of the major causes of liver disease affecting an estimated
170 million people culminating in 300,000 deaths from cirrhosis or liver cancer. NS5B is one …

Sofosbuvir and its tri-phosphate metabolite inhibit the RNA-dependent RNA polymerase activity of non-structural protein 5 from the Kyasanur forest disease virus

M Malik, P Vijayan, DK Jagannath, RK Mishra… - Biochemical and …, 2023 - Elsevier
Kyasanur forest disease is a neglected zoonotic disease caused by a single-stranded RNA-
based flavivirus, the incidence of which was first recorded in 1957 in the Southern part of …

Structural and energetic analysis of NS5 protein inhibition by small molecules in Japanese encephalitis virus using machine learning and steered molecular dynamics …

AY Alhazmi, FR Khan, Z Rehman… - Journal of …, 2024 - Taylor & Francis
One of the viral diseases that affect millions of people around the world, particularly in
develo** countries, is Japanese encephalitis (JE). In this study, the conserved protein of …