Abstract RNA polymerase II (Pol II) core promoters are specialized DNA sequences at
transcription start sites of protein-coding and non-coding genes that support the assembly of …

With the completion of the human genome sequence, attention turned to identifying and
annotating its functional DNA elements. As a complement to genetic and comparative …

Brains contain networks of interconnected neurons and so knowing the network architecture
is essential for understanding brain function. We therefore mapped the synaptic-resolution …

FlyBase provides a centralized resource for the genetic and genomic data of Drosophila
melanogaster. As FlyBase enters our fourth decade of service to the research community …

Light-sheet imaging of cleared and expanded samples creates terabyte-sized datasets that
consist of many unaligned three-dimensional image tiles, which must be reconstructed …

Optogenetic tools enable examination of how specific cell types contribute to brain circuit
functions. A long-standing question is whether it is possible to independently activate two …

We identified the neurons comprising the Drosophila mushroom body (MB), an associative
center in invertebrate brains, and provide a comprehensive map describing their potential …

In neural networks that store information in their connection weights, there is a tradeoff
between sensitivity and stability,. Connections must be plastic to incorporate new …

BigNeuron is an open community bench-testing platform with the goal of setting open
standards for accurate and fast automatic neuron tracing. We gathered a diverse set of …

We describe the development and application of methods for high-throughput
neuroanatomy in Drosophila using light microscopy. These tools enable efficient multicolor …