The pentose phosphate pathway (PPP) is a fundamental component of cellular metabolism.
The PPP is important to maintain carbon homoeostasis, to provide precursors for nucleotide …

Kinetic models are critical to predict the dynamic behaviour of metabolic networks.
Mechanistic kinetic models for large networks remain uncommon due to the difficulty of fitting …

Peroxisomes of organisms belonging to the protist group Kinetoplastea, which include
trypanosomatid parasites of the genera Trypanosoma and Leishmania, are unique in …

The human pathogenic trypanosomatid species collectively called the “TriTryp parasites”–
Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp.–have complex life cycles …

Metabolomics coupled with heavy-atom isotope-labelled glucose has been used to probe
the metabolic pathways active in cultured bloodstream form trypomastigotes of …

Parasitic trypanosomatids cause important diseases. Dissecting the biochemistry of these
organisms offers a means of discovering targets against which inhibitors may be designed …

The development of drugs that can inactivate disease-causing cells (eg cancer cells or
parasites) without causing collateral damage to healthy or to host cells is complicated by the …

Introduced about a century ago, suramin remains a frontline drug for the management of
early-stage East African trypanosomiasis (slee** sickness). Cellular entry into the …

Bloodstream form African trypanosomes are thought to rely exclusively upon glycolysis,
using glucose as a substrate, for ATP production. Indeed, the pathway has long been …

phosphogluconate dehydrogenase (6PGDH) participates in pentose phosphate pathway of
glucose metabolism by catalyzing oxidative decarboxylation of 6-phsophogluconate (6PG) …