Background Neuroplasticity refers to the inherently dynamic biological capacity of the central
nervous system (CNS) to undergo maturation, change structurally and functionally in …

Status epilepticus is a life-threatening neurological emergency that affects both adults and
children. Approximately 36% of episodes of status epilepticus do not respond to the current …

Synaptic inhibition plays a crucial role in regulating neuronal excitability, which is the
foundation of nervous system function. This inhibition is largely mediated by the …

GABA is the major inhibitory neurotransmitter that counterbalances excitation in the mature
brain. The inhibitory action of GABA relies on the inflow of chloride ions (Cl−), which …

Targeted, noninvasive neuromodulation of the brain of an otherwise awake subject could
revolutionize both basic and clinical neuroscience. Toward this goal, we have developed …

Abstract The Na–K–2Cl cotransporter NKCC1 and the neuron-specific K–Cl cotransporter
KCC2 are considered attractive CNS drug targets because altered neuronal chloride …

Objective In the absence of controlled trials, treatment of neonatal seizures has changed
minimally despite poor drug efficacy. We tested bumetanide added to phenobarbital to treat …

The epilepsies are common neurologic disorders characterized by spontaneous recurrent
seizures. Boys, girls, men, and women of all ages are affected by epilepsy and, in many …

Bumetanide (BTN or BUM) is a FDA-approved potent loop diuretic (LD) that acts by
antagonizing sodium-potassium-chloride (Na-K-Cl) cotransporters, NKCC1 (SLc12a2) and …

Abstract The K+-Cl− co-transporter KCC2 is a neuron-specific, Cl− extruder that uses K+
gradient for maintaining low intracellular [Cl−]. It is indeed well established that sustaining …