Bacillus subtilis: a universal cell factory for industry, agriculture, biomaterials and medicine

Y Su, C Liu, H Fang, D Zhang - Microbial cell factories, 2020 - Springer
Due to its clear inherited backgrounds as well as simple and diverse genetic manipulation
systems, Bacillus subtilis is the key Gram-positive model bacterium for studies on physiology …

Bacillus and Streptomyces spp. as hosts for production of industrially relevant enzymes

S Vojnovic, I Aleksic, T Ilic-Tomic, M Stevanovic… - Applied microbiology …, 2024 - Springer
The application of enzymes is expanding across diverse industries due to their nontoxic and
biodegradable characteristics. Another advantage is their cost-effectiveness, reflected in …

Exploitation of Bacillus subtilis as a robust workhorse for production of heterologous proteins and beyond

W Cui, L Han, F Suo, Z Liu, L Zhou, Z Zhou - World Journal of Microbiology …, 2018 - Springer
Bacillus subtilis, belonging to the type species of Bacillus, is a type of soil-derived, low% G+
C, endospore-forming Gram-positive bacterium. After the discovery of B. subtilis 168 that …

Bacterial epigenetics and its implication for agriculture, probiotics development, and biotechnology design

TL Povolotsky, HL Barazany, Y Shacham… - Biotechnology …, 2024 - Elsevier
In their natural habitats, organisms encounter numerous external stimuli and must be able to
sense and adapt to those stimuli to survive. Unlike mutations, epigenetic changes do not …

Production of proteins and commodity chemicals using engineered Bacillus subtilis platform strain

Q Zhang, Y Wu, M Gong, H Zhang, Y Liu… - Essays in …, 2021 - portlandpress.com
Currently, increasing demand of biochemicals produced from renewable resources has
motivated researchers to seek microbial production strategies instead of traditional chemical …

Optimal secretion of alkali-tolerant xylanase in Bacillus subtilis by signal peptide screening

W Zhang, M Yang, Y Yang, J Zhan, Y Zhou… - Applied Microbiology and …, 2016 - Springer
Xylanases are industrially important enzymes for xylan digestion. We experimentally
screened over 114 Sec and 24 Tat pathway signal peptides, with two different promoters, for …

Integrated Genomics and Transcriptomics Provide Insights into Salt Stress Response in Bacillus subtilis ACP81 from Moso Bamboo Shoot (Phyllostachys praecox) …

Q Li, Z Huang, Z Zhong, F Bian, X Zhang - Microorganisms, 2024 - mdpi.com
Salt stress is detrimental to the survival of microorganisms, and only a few bacterial species
produce hydrolytic enzymes. In this study, we investigated the expression of salt stress …

A Review on Recent Advancement in Expression Strategies Used in Bacillus subtilis

S Ejaz, H Khan, N Sarwar, SM Aqeel… - Protein and Peptide …, 2022 - benthamdirect.com
Bacillus subtilis is a Gram-positive bacterium that has gained an unprecedented reputation
as an expression system at the industrial scale due to characteristics, such as GRAS …

Engineering Geobacillus thermodenitrificans to introduce cellulolytic activity; expression of native and heterologous cellulase genes

MJA Daas, B Nijsse, AHP van de Weijer… - BMC …, 2018 - Springer
Background Consolidated bioprocessing (CBP) is a cost-effective approach for the
conversion of lignocellulosic biomass to biofuels and biochemicals. The enzymatic …

Synergistic regulation of chassis cell growth and screening of promoters, signal peptides and fusion protein linkers for enhanced recombinant protein expression in …

B Wang, Y Wu, X Lv, L Liu, J Li, G Du, J Chen… - International Journal of …, 2024 - Elsevier
Growth-advantageous microbial chassis cells are beneficial for shortening fermentation
period and boosting biomolecule productivity. This study focused on enhancing recombinant …