Mathematical modeling of the glucose–insulin system: A review

P Palumbo, S Ditlevsen, A Bertuzzi… - Mathematical …, 2013 - Elsevier
Mathematical modeling of the glucose–insulin feedback system is necessary to the
understanding of the homeostatic control, to analyze experimental data, to identify and …

Modeling impulsive injections of insulin: towards artificial pancreas

M Huang, J Li, X Song, H Guo - SIAM Journal on Applied Mathematics, 2012 - SIAM
We propose two novel mathematical models with impulsive injection of insulin or its
analogues for type 1 and type 2 diabetes mellitus. One model incorporates the periodic …

[HTML][HTML] Mathematical modelling of glucose dynamics

B Huard, G Kirkham - Current Opinion in Endocrine and Metabolic …, 2022 - Elsevier
The accurate regulation of glucose within humans is an essential feature of homeostasis. It
optimises energy release in the muscles and organs. Glucose rhythms driven by internal …

A simple modeling framework for prediction in the human glucose–insulin system

M Sirlanci, ME Levine, CC Low Wang… - … Journal of Nonlinear …, 2023 - pubs.aip.org
Forecasting blood glucose (BG) levels with routinely collected data is useful for glycemic
management. BG dynamics are nonlinear, complex, and nonstationary, which can be …

Modelling alcoholism as a contagious disease: a mathematical model with awareness programs and time delay

SH Ma, HF Huo, XY Meng - Discrete Dynamics in Nature and …, 2015 - Wiley Online Library
A dynamic alcohol consumption model with awareness programs and time delay is
formulated and analyzed. The aim of this model is to capture the effects of awareness …

Stability analysis and numerical simulations of IVGTT glucose-insulin interaction models with two time delays

S Saber, A Alalyani - Mathematical Modelling and Analysis, 2022 - jau.vgtu.lt
This paper presents a systematic study of a mathematical model of glucose and insulin
interaction with two time delays, with a focus on analytical studies, bifurcation analysis, and …

[HTML][HTML] A mathematical model of food intake

M Chudtong, A De Gaetano - Mathematical Biosciences and …, 2021 - aimspress.com
The metabolic, hormonal and psychological determinants of the feeding behavior in humans
are numerous and complex. A plausible model of the initiation, continuation and cessation of …

Modeling impulsive insulin delivery in insulin pump with time delays

X Song, M Huang, J Li - SIAM Journal on Applied Mathematics, 2014 - SIAM
We continue our attempt of modeling the open-loop control of glucose level by impulsive
insulin injections. Several time delays exist in the system. The delays include the time …

[HTML][HTML] Oscillatory dynamics of an intravenous glucose tolerance test model with delay interval

X Shi, Y Kuang, A Makroglou… - … Journal of Nonlinear …, 2017 - pubs.aip.org
Type 2 diabetes mellitus (T2DM) has become prevalent pandemic disease in view of the
modern life style. Both diabetic population and health expenses grow rapidly according to …

Is dynamic autocrine insulin signaling possible? A mathematical model predicts picomolar concentrations of extracellular monomeric insulin within human pancreatic …

M Wang, J Li, GE Lim, JD Johnson - PLoS One, 2013 - journals.plos.org
Insulin signaling is essential for-cell survival and proliferation in vivo. Insulin also has potent
mitogenic and anti-apoptotic actions on cultured-cells, with maximum effect in the high …