The nuclear factor-kappaB (NF-κB) signaling pathway is considered as a potential
therapeutic target in cancer therapy. It has been well established that transcription factor NF …

Breast cancer is the most malignant tumor in women, and there is no absolute cure for it.
Although treatment modalities including surgery, chemotherapy, and radiotherapy are …

Cancer cells frequently display intrinsic or acquired resistance to chemically diverse
anticancer drugs, limiting therapeutic success. Among the main mechanisms of this …

There is increasing evidence that malignant tumors are initiated and maintained by a sub-
population of tumor cells that have similar biological properties to normal adult stem cells …

Cancer remains a leading cause of morbidity and mortality worldwide. Hence, the increase
in cancer cases observed in the elderly population, as well as in children and adolescents …

The improvement of cancer chemotherapy remains a major challenge, and thus new drugs
are urgently required to develop new treatment regimes. Curcumin, a polyphenolic …

Multidrug resistance is a major factor causing the failure of cancer chemotherapy. Efflux
pumps of the ATP-binding cassette (ABC) transporter family expel a large array of diverse …

The co-administration of anticancer drugs and P-glycoprotein (P-gp) inhibitors was a
treatment strategy to surmount multidrug resistance (MDR) in anticancer chemotherapy. In …

Even though various treatment methods are available for cancer, the death curve is not
reducing. The diagnosis of cancer at the fourth stage and drug resistance are the leading …

Aims To investigate the collateral sensitivity (CS) of ABCB1-positive multidrug resistant
(MDR) colorectal cancer cells to the survivin inhibitor MX106–4C and the mechanism …