Ferroptosis is a mechanism of regulated necrotic cell death characterized by iron-
dependent, lipid peroxidation-driven membrane destruction that can be inhibited by …

200 billion red blood cells (RBCs) are produced every day, requiring more than 2× 10 15
iron atoms every second to maintain adequate erythropoiesis. These numbers translate into …

Cellular iron, at the physiological level, is essential to maintain several metabolic pathways,
while an excess of free iron may cause oxidative damage and/or provoke cell death …

Iron is necessary for life, but can also cause cell death. Accordingly, cells evolved a robust,
tightly regulated suite of genes for maintaining iron homeostasis. Previous mechanistic …

Iron is an essential element that is indispensable for life. The delicate physiological body
iron balance is maintained by both systemic and cellular regulatory mechanisms. The iron …

This is the fifth in the series of reviews developed as part of the Biomarkers of Nutrition for
Development (BOND) program. The BOND Iron Expert Panel (I-EP) reviewed the extant …

Introduction: Mitochondria are cellular organelles that perform numerous bioenergetic,
biosynthetic, and regulatory functions and play a central role in iron metabolism …

Iron dyshomeostasis can cause neuronal damage to iron-sensitive brain regions.
Neurodegeneration with brain iron accumulation reflects a group of disorders caused by iron …

Duality of iron as an essential cofactor of many enzymatic metabolic processes and as a
catalyst of poorly controlled redox-cycling reactions defines its possible biological beneficial …

Redox balance is essential for normal brain, hence dis-coordinated oxidative reactions
leading to neuronal death, including programs of regulated death, are commonly viewed as …