Mass spectrometry imaging in drug development
Drug discovery and development is a high-risk, expensive endeavor and it commonly takes
about 10− 15 years to obtain marketing approval from project inception. 1 Research efforts …
about 10− 15 years to obtain marketing approval from project inception. 1 Research efforts …
MALDI imaging mass spectrometry: bridging biology and chemistry in drug development
Our understanding of drug tissue distribution impacts a number of areas in drug
development, including: pharmacology, pharmacokinetics, safety, drug–drug interactions …
development, including: pharmacology, pharmacokinetics, safety, drug–drug interactions …
Tuberculosis: the drug development pipeline at a glance
Tuberculosis is a major disease causing every year 1.8 million deaths worldwide and
represents the leading cause of mortality resulting from a bacterial infection. Introduction in …
represents the leading cause of mortality resulting from a bacterial infection. Introduction in …
Quantitative mass spectrometry imaging of propranolol and olanzapine using tissue extinction calculation as normalization factor
G Hamm, D Bonnel, R Legouffe, F Pamelard… - Journal of …, 2012 - Elsevier
In order to quantify small molecules at the early stage of drug discovery, we developed a
quantitation approach based on mass spectrometry imaging (MSI) using matrix-assisted …
quantitation approach based on mass spectrometry imaging (MSI) using matrix-assisted …
Design and performance of a novel interface for combined matrix-assisted laser desorption ionization at elevated pressure and electrospray ionization with orbitrap …
Matrix-Assisted Laser Desorption Ionization, MALDI, has been increasingly used in a variety
of biomedical applications, including tissue imaging of clinical tissue samples, and in drug …
of biomedical applications, including tissue imaging of clinical tissue samples, and in drug …
Development of liquid microjunction extraction strategy for improving protein identification from tissue sections
MALDI Mass Spectrometry Imaging has shown important potential for molecular
classification and pathology marker discovery. Protein markers identification is therefore of …
classification and pathology marker discovery. Protein markers identification is therefore of …
Desorption electrospray ionization and matrix-assisted laser desorption/ionization as imaging approaches for biological samples analysis
The imaging of biological tissues can offer valuable information about the sample
composition, which improves the understanding of analyte distribution in such complex …
composition, which improves the understanding of analyte distribution in such complex …
Detection and characterization of simvastatin and its metabolites in rat tissues and biological fluids using MALDI high resolution mass spectrometry approach
Simvastatin (SV) is a hypolipidemic agent, and it is the 2nd most widely prescribed lipid-
lowering drug. Here, the detection and characterization of SV and its metabolites was …
lowering drug. Here, the detection and characterization of SV and its metabolites was …
Targeted mass spectrometry imaging: Specific targeting mass spectrometry imaging technologies from history to perspective
Since its introduction during the last decade, MALDI mass spectrometry imaging (MSI) is
now a routine technique in biology. Nevertheless, a missing link exists in MALDI MSI. Lipids …
now a routine technique in biology. Nevertheless, a missing link exists in MALDI MSI. Lipids …
DMSO-enhanced MALDI MS imaging with normalization against a deuterated standard for relative quantification of dasatinib in serial mouse pharmacology studies
S Schulz, D Gerhardt, B Meyer, M Seegel… - Analytical and …, 2013 - Springer
Matrix-assisted laser desorption/ionization mass spectrometry imaging is an emerging
powerful technique in drug metabolism and pharmacokinetics research. Despite recent …
powerful technique in drug metabolism and pharmacokinetics research. Despite recent …