Drugging the efferocytosis process: concepts and opportunities
The daily removal of billions of apoptotic cells in the human body via the process of
efferocytosis is essential for homeostasis. To allow for this continuous efferocytosis, rapid …
efferocytosis is essential for homeostasis. To allow for this continuous efferocytosis, rapid …
Neutrophils in COVID-19
Strong evidence has been accumulated since the beginning of the COVID-19 pandemic that
neutrophils play an important role in the pathophysiology, particularly in those with severe …
neutrophils play an important role in the pathophysiology, particularly in those with severe …
Neutrophil intrinsic and extrinsic regulation of NETosis in health and disease
Neutrophil extracellular traps (NETs) evolved to protect the host against microbial infections
and are formed by a web-like structure of DNA that is decorated with antimicrobial effectors …
and are formed by a web-like structure of DNA that is decorated with antimicrobial effectors …
Diversity of macrophages in lung homeostasis and diseases
F Hou, K **ao, L Tang, L **e - Frontiers in immunology, 2021 - frontiersin.org
Lung macrophages play important roles in the maintenance of homeostasis, pathogen
clearance and immune regulation. The different types of pulmonary macrophages and their …
clearance and immune regulation. The different types of pulmonary macrophages and their …
Neutrophils and NETs in modulating acute and chronic inflammation
Neutrophils are an absolutely essential part of the innate immune system, playing an
essential role in the control of infectious diseases but more recently are also being viewed …
essential role in the control of infectious diseases but more recently are also being viewed …
Targeting neutrophils for promoting the resolution of inflammation
JG Filep - Frontiers in immunology, 2022 - frontiersin.org
Acute inflammation is a localized and self-limited innate host-defense mechanism against
invading pathogens and tissue injury. Neutrophils, the most abundant immune cells in …
invading pathogens and tissue injury. Neutrophils, the most abundant immune cells in …
Neutrophil extracellular trap formation: physiology, pathology, and pharmacology
Neutrophil extracellular traps (NETs), a unique DNA framework decorated with antimicrobial
peptides, have been in the scientific limelight for their role in a variety of pathologies ranging …
peptides, have been in the scientific limelight for their role in a variety of pathologies ranging …
Neutrophils in the initiation and resolution of acute pulmonary inflammation: understanding biological function and therapeutic potential
Acute respiratory distress syndrome (ARDS) is the often fatal sequelae of a broad range of
precipitating conditions. Despite decades of intensive research and clinical trials there …
precipitating conditions. Despite decades of intensive research and clinical trials there …
Targeting neutrophils to treat acute respiratory distress syndrome in coronavirus disease
This review describes targeting neutrophils as a potential therapeutic strategy for acute
respiratory distress syndrome (ARDS) associated with coronavirus disease 2019 (COVID …
respiratory distress syndrome (ARDS) associated with coronavirus disease 2019 (COVID …
Efferocytosis and its role in inflammatory disorders
Y Ge, M Huang, Y Yao - Frontiers in cell and developmental biology, 2022 - frontiersin.org
Efferocytosis is the effective clearance of apoptotic cells by professional and non-
professional phagocytes. The process is mechanically different from other forms of …
professional phagocytes. The process is mechanically different from other forms of …