Drugging the efferocytosis process: concepts and opportunities

P Mehrotra, KS Ravichandran - Nature reviews Drug discovery, 2022 - nature.com
The daily removal of billions of apoptotic cells in the human body via the process of
efferocytosis is essential for homeostasis. To allow for this continuous efferocytosis, rapid …

Neutrophils in COVID-19

N Reusch, E De Domenico, L Bonaguro… - Frontiers in …, 2021 - frontiersin.org
Strong evidence has been accumulated since the beginning of the COVID-19 pandemic that
neutrophils play an important role in the pathophysiology, particularly in those with severe …

Neutrophil intrinsic and extrinsic regulation of NETosis in health and disease

V Poli, I Zanoni - Trends in microbiology, 2023 - cell.com
Neutrophil extracellular traps (NETs) evolved to protect the host against microbial infections
and are formed by a web-like structure of DNA that is decorated with antimicrobial effectors …

Diversity of macrophages in lung homeostasis and diseases

F Hou, K **ao, L Tang, L **e - Frontiers in immunology, 2021 - frontiersin.org
Lung macrophages play important roles in the maintenance of homeostasis, pathogen
clearance and immune regulation. The different types of pulmonary macrophages and their …

Neutrophils and NETs in modulating acute and chronic inflammation

FVS Castanheira, P Kubes - … Journal of the American Society of …, 2019 - ashpublications.org
Neutrophils are an absolutely essential part of the innate immune system, playing an
essential role in the control of infectious diseases but more recently are also being viewed …

Targeting neutrophils for promoting the resolution of inflammation

JG Filep - Frontiers in immunology, 2022 - frontiersin.org
Acute inflammation is a localized and self-limited innate host-defense mechanism against
invading pathogens and tissue injury. Neutrophils, the most abundant immune cells in …

Neutrophil extracellular trap formation: physiology, pathology, and pharmacology

M Ravindran, MA Khan, N Palaniyar - Biomolecules, 2019 - mdpi.com
Neutrophil extracellular traps (NETs), a unique DNA framework decorated with antimicrobial
peptides, have been in the scientific limelight for their role in a variety of pathologies ranging …

Neutrophils in the initiation and resolution of acute pulmonary inflammation: understanding biological function and therapeutic potential

PMD Potey, AG Rossi, CD Lucas… - The Journal of …, 2019 - Wiley Online Library
Acute respiratory distress syndrome (ARDS) is the often fatal sequelae of a broad range of
precipitating conditions. Despite decades of intensive research and clinical trials there …

Targeting neutrophils to treat acute respiratory distress syndrome in coronavirus disease

CC Chiang, M Korinek, WJ Cheng… - Frontiers in …, 2020 - frontiersin.org
This review describes targeting neutrophils as a potential therapeutic strategy for acute
respiratory distress syndrome (ARDS) associated with coronavirus disease 2019 (COVID …

Efferocytosis and its role in inflammatory disorders

Y Ge, M Huang, Y Yao - Frontiers in cell and developmental biology, 2022 - frontiersin.org
Efferocytosis is the effective clearance of apoptotic cells by professional and non-
professional phagocytes. The process is mechanically different from other forms of …