Advancing conventional open‐loop DBS as a therapy for PD is crucial for overcoming
important issues such as the delicate balance between beneficial and adverse effects and …

Movement abnormalities of Parkinson's disease (PD) arise from disordered neural activity in
multiple interconnected brain structures. The planning and execution of movement requires …

Studies of the pathophysiology of parkinsonism (specifically akinesia and bradykinesia)
have a long history and primarily model the consequences of dopamine loss in the basal …

Elevated synchronized oscillatory activity in the beta band has been hypothesized to be a
pathophysiological marker of Parkinson's disease (PD). Recent studies have suggested that …

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) and globus pallidus internus
(GPi) is an effective treatment for parkinsonian motor signs. Though its therapeutic …

Both phase-amplitude coupling (PAC) and beta-bursts in the subthalamic nucleus have
been significantly linked to symptom severity in Parkinson's disease (PD) in humans and …

Introduction Parkinson's disease (PD) is a neurodegenerative disorder affecting millions of
patients. Closed-Loop Deep Brain Stimulation (CL-DBS) is a therapy that can alleviate the …

Parkinson's disease (PD) is a progressive neurodegenerative movement disorder affecting
over 10 million people worldwide. In the 1930s and 1940s there was little understanding …

Despite having remarkable utility in treating movement disorders, the lack of understanding
of the underlying mechanisms of high-frequency deep brain stimulation (DBS) is a main …

Background Approaches to predictably control neural oscillations are needed to understand
their causal role in brain function in healthy or diseased states and to advance the …