Synthetic chromosomes, genomes, viruses, and cells

JC Venter, JI Glass, CA Hutchison, S Vashee - Cell, 2022 - cell.com
Synthetic genomics is the construction of viruses, bacteria, and eukaryotic cells with
synthetic genomes. It involves two basic processes: synthesis of complete genomes or …

Designing a synthetic moss genome using GenoDesigner

W Yu, S Zhang, S Zhao, L Chen, J Cao, H Ye, J Yan… - Nature plants, 2024 - nature.com
The de novo synthesis of genomes has made unprecedented progress and achieved
milestones, particularly in bacteria and yeast. However, the process of synthesizing a …

Total synthesis of Escherichia coli with a recoded genome

J Fredens, K Wang, D de la Torre, LFH Funke… - Nature, 2019 - nature.com
Nature uses 64 codons to encode the synthesis of proteins from the genome, and chooses 1
sense codon—out of up to 6 synonyms—to encode each amino acid. Synonymous codon …

Design of a synthetic yeast genome

SM Richardson, LA Mitchell, G Stracquadanio, K Yang… - Science, 2017 - science.org
We describe complete design of a synthetic eukaryotic genome, Sc2. 0, a highly modified
Saccharomyces cerevisiae genome reduced in size by nearly 8%, with 1.1 megabases of …

High‐Performance CsPbIxBr3‐x All‐Inorganic Perovskite Solar Cells with Efficiency over 18% via Spontaneous Interfacial Manipulation

Y Zheng, X Yang, R Su, P Wu… - Advanced Functional …, 2020 - Wiley Online Library
Cesium‐based all‐inorganic halide perovskites solar cells (PSCs) have recently attracted
increasing attention. Currently, due to the existence of high defects density and unoptimized …

Synthesis, debugging, and effects of synthetic chromosome consolidation: synVI and beyond

LA Mitchell, A Wang, G Stracquadanio, Z Kuang… - Science, 2017 - science.org
INTRODUCTION Total synthesis of designer chromosomes and genomes is a new
paradigm for the study of genetics and biological systems. The Sc2. 0 project is building a …

Deep functional analysis of synII, a 770-kilobase synthetic yeast chromosome

Y Shen, Y Wang, T Chen, F Gao, J Gong, D Abramczyk… - Science, 2017 - science.org
INTRODUCTION Although much effort has been devoted to studying yeast in the past few
decades, our understanding of this model organism is still limited. Rapidly develo** DNA …

Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions

Y Zhao, C Coelho, AL Hughes, L Lazar-Stefanita… - Cell, 2023 - cell.com
The Sc2. 0 project is building a eukaryotic synthetic genome from scratch. A major milestone
has been achieved with all individual Sc2. 0 chromosomes assembled. Here, we describe …

Engineering the ribosomal DNA in a megabase synthetic chromosome

W Zhang, G Zhao, Z Luo, Y Lin, L Wang, Y Guo… - Science, 2017 - science.org
INTRODUCTION It has long been an interesting question whether a living cell can be
constructed from scratch in the lab, a goal that may not be realized anytime soon …

An artificial chromosome for data storage

W Chen, M Han, J Zhou, Q Ge, P Wang… - National Science …, 2021 - academic.oup.com
DNA digital storage provides an alternative for information storage with high density and
long-term stability. Here, we report the de novo design and synthesis of an artificial …