Synthetic chromosomes, genomes, viruses, and cells
Synthetic genomics is the construction of viruses, bacteria, and eukaryotic cells with
synthetic genomes. It involves two basic processes: synthesis of complete genomes or …
synthetic genomes. It involves two basic processes: synthesis of complete genomes or …
Designing a synthetic moss genome using GenoDesigner
The de novo synthesis of genomes has made unprecedented progress and achieved
milestones, particularly in bacteria and yeast. However, the process of synthesizing a …
milestones, particularly in bacteria and yeast. However, the process of synthesizing a …
Total synthesis of Escherichia coli with a recoded genome
Nature uses 64 codons to encode the synthesis of proteins from the genome, and chooses 1
sense codon—out of up to 6 synonyms—to encode each amino acid. Synonymous codon …
sense codon—out of up to 6 synonyms—to encode each amino acid. Synonymous codon …
Design of a synthetic yeast genome
We describe complete design of a synthetic eukaryotic genome, Sc2. 0, a highly modified
Saccharomyces cerevisiae genome reduced in size by nearly 8%, with 1.1 megabases of …
Saccharomyces cerevisiae genome reduced in size by nearly 8%, with 1.1 megabases of …
High‐Performance CsPbIxBr3‐x All‐Inorganic Perovskite Solar Cells with Efficiency over 18% via Spontaneous Interfacial Manipulation
Cesium‐based all‐inorganic halide perovskites solar cells (PSCs) have recently attracted
increasing attention. Currently, due to the existence of high defects density and unoptimized …
increasing attention. Currently, due to the existence of high defects density and unoptimized …
Synthesis, debugging, and effects of synthetic chromosome consolidation: synVI and beyond
INTRODUCTION Total synthesis of designer chromosomes and genomes is a new
paradigm for the study of genetics and biological systems. The Sc2. 0 project is building a …
paradigm for the study of genetics and biological systems. The Sc2. 0 project is building a …
Deep functional analysis of synII, a 770-kilobase synthetic yeast chromosome
INTRODUCTION Although much effort has been devoted to studying yeast in the past few
decades, our understanding of this model organism is still limited. Rapidly develo** DNA …
decades, our understanding of this model organism is still limited. Rapidly develo** DNA …
Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions
The Sc2. 0 project is building a eukaryotic synthetic genome from scratch. A major milestone
has been achieved with all individual Sc2. 0 chromosomes assembled. Here, we describe …
has been achieved with all individual Sc2. 0 chromosomes assembled. Here, we describe …
Engineering the ribosomal DNA in a megabase synthetic chromosome
INTRODUCTION It has long been an interesting question whether a living cell can be
constructed from scratch in the lab, a goal that may not be realized anytime soon …
constructed from scratch in the lab, a goal that may not be realized anytime soon …
An artificial chromosome for data storage
W Chen, M Han, J Zhou, Q Ge, P Wang… - National Science …, 2021 - academic.oup.com
DNA digital storage provides an alternative for information storage with high density and
long-term stability. Here, we report the de novo design and synthesis of an artificial …
long-term stability. Here, we report the de novo design and synthesis of an artificial …