[HTML][HTML] Rechanneling the cardiac proarrhythmia safety paradigm: a meeting report from the Cardiac Safety Research Consortium
PT Sager, G Gintant, JR Turner, S Pettit… - American heart …, 2014 - Elsevier
This white paper provides a summary of a scientific proposal presented at a Cardiac Safety
Research Consortium/Health and Environmental Sciences Institute/Food and Drug …
Research Consortium/Health and Environmental Sciences Institute/Food and Drug …
Evolution of strategies to improve preclinical cardiac safety testing
G Gintant, PT Sager, N Stockbridge - Nature reviews Drug discovery, 2016 - nature.com
The early and efficient assessment of cardiac safety liabilities is essential to confidently
advance novel drug candidates. This article discusses evolving mechanistically based …
advance novel drug candidates. This article discusses evolving mechanistically based …
Chaste: an open source C++ library for computational physiology and biology
Chaste—C ancer, H eart A nd S oft T issue E nvironment—is an open source C++ library for
the computational simulation of mathematical models developed for physiology and biology …
the computational simulation of mathematical models developed for physiology and biology …
The Lambeth Conventions (II): guidelines for the study of animal and human ventricular and supraventricular arrhythmias
The 'Lambeth Conventions' is a guidance document, written in 1987 (Walker et al., 1988),
intended to be of practical value in the investigation of experimental arrhythmias induced by …
intended to be of practical value in the investigation of experimental arrhythmias induced by …
[HTML][HTML] Uncertainty and variability in models of the cardiac action potential: Can we build trustworthy models?
Cardiac electrophysiology models have been developed for over 50 years, and now include
detailed descriptions of individual ion currents and sub-cellular calcium handling. It is …
detailed descriptions of individual ion currents and sub-cellular calcium handling. It is …
Uncertainty and variability in computational and mathematical models of cardiac physiology
Key points Mathematical and computational models of cardiac physiology have been an
integral component of cardiac electrophysiology since its inception, and are collectively …
integral component of cardiac electrophysiology since its inception, and are collectively …
Accounting for variability in ion current recordings using a mathematical model of artefacts in voltage-clamp experiments
Mathematical models of ion channels, which constitute indispensable components of action
potential models, are commonly constructed by fitting to whole-cell patch-clamp data. In a …
potential models, are commonly constructed by fitting to whole-cell patch-clamp data. In a …
Considering discrepancy when calibrating a mechanistic electrophysiology model
Uncertainty quantification (UQ) is a vital step in using mathematical models and simulations
to take decisions. The field of cardiac simulation has begun to explore and adopt UQ …
to take decisions. The field of cardiac simulation has begun to explore and adopt UQ …
Screening system for drug-induced arrhythmogenic risk combining a patch clamp and heart simulator
To save time and cost for drug discovery, a paradigm shift in cardiotoxicity testing is
required. We introduce a novel screening system for drug-induced arrhythmogenic risk that …
required. We introduce a novel screening system for drug-induced arrhythmogenic risk that …
Comprehensive in vitro Proarrhythmia Assay, a novel in vitro/in silico paradigm to detect ventricular proarrhythmic liability: a visionary 21st century initiative
I Cavero, H Holzgrefe - Expert opinion on drug safety, 2014 - Taylor & Francis
Introduction: The Comprehensive in vitro Proarrhythmia Assay (CiPA) is a novel safety
screening proposal intended to replace the 2005 regulatory strategy recommended by the …
screening proposal intended to replace the 2005 regulatory strategy recommended by the …