Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
JM Kyriakis, J Avruch - Physiological reviews, 2001 - journals.physiology.org
The molecular details of mammalian stress-activated signal transduction pathways have
only begun to be dissected. This, despite the fact that the impact of these pathways on the …
only begun to be dissected. This, despite the fact that the impact of these pathways on the …
Ca2+ Sensitivity of Smooth Muscle and Nonmuscle Myosin II: Modulated by G Proteins, Kinases, and Myosin Phosphatase
AP Somlyo, AV Somlyo - Physiological reviews, 2003 - journals.physiology.org
Somlyo, Andrew P., and Avril V. Somlyo. Ca2+ Sensitivity of Smooth Muscle and Nonmuscle
Myosin II: Modulated by G Proteins, Kinases, and Myosin Phosphatase. Physiol Rev 83 …
Myosin II: Modulated by G Proteins, Kinases, and Myosin Phosphatase. Physiol Rev 83 …
[HTML][HTML] Rho and Rac take center stage
Many features of cell behavior are regulated by Rho family GTPases, but the most profound
effects of these proteins are on the actin cytoskeleton and it was these that first drew …
effects of these proteins are on the actin cytoskeleton and it was these that first drew …
[HTML][HTML] Cell migration: Rho GTPases lead the way
M Raftopoulou, A Hall - Developmental biology, 2004 - Elsevier
Rho GTPases control signal transduction pathways that link cell surface receptors to a
variety of intracellular responses. They are best known as regulators of the actin …
variety of intracellular responses. They are best known as regulators of the actin …
Random versus directionally persistent cell migration
Directional migration is an important component of cell motility. Although the basic
mechanisms of random cell movement are well characterized, no single model explains the …
mechanisms of random cell movement are well characterized, no single model explains the …
Rho GTPases and cell migration
AJ Ridley - Journal of cell science, 2001 - journals.biologists.com
Cell migration involves dynamic and spatially regulated changes to the cytoskeleton and cell
adhesion. The Rho GTPases play key roles in coordinating the cellular responses required …
adhesion. The Rho GTPases play key roles in coordinating the cellular responses required …
Protein interactions at endothelial junctions and signaling mechanisms regulating endothelial permeability
YA Komarova, K Kruse, D Mehta, AB Malik - Circulation research, 2017 - Am Heart Assoc
The monolayer of endothelial cells lining the vessel wall forms a semipermeable barrier (in
all tissue except the relatively impermeable blood–brain and inner retinal barriers) that …
all tissue except the relatively impermeable blood–brain and inner retinal barriers) that …
Biology of the p21-activated kinases
GM Bokoch - Annual review of biochemistry, 2003 - annualreviews.org
▪ Abstract The p21-activated kinases (PAKs) 1–3 are serine/threonine protein kinases whose
activity is stimulated by the binding of active Rac and Cdc42 GTPases. Our understanding of …
activity is stimulated by the binding of active Rac and Cdc42 GTPases. Our understanding of …
Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics
DC Edwards, LC Sanders, GM Bokoch, GN Gill - Nature cell biology, 1999 - nature.com
Extracellular signals regulate actin dynamics through small GTPases of the Rho/Rac/Cdc42
(p21) family. Here we show that p21-activated kinase (Pak1) phosphorylates LIM-kinase at …
(p21) family. Here we show that p21-activated kinase (Pak1) phosphorylates LIM-kinase at …
Rho GTPases in neuronal morphogenesis
L Luo - Nature Reviews Neuroscience, 2000 - nature.com
The Rho family of small GTPases act as intracellular molecular switches that transduce
signals from extracellular stimuli to the actin cytoskeleton and the nucleus. Recent evidence …
signals from extracellular stimuli to the actin cytoskeleton and the nucleus. Recent evidence …