Immune checkpoint blockade (ICB) therapies have achieved remarkable clinical responses
in patients with many different types of cancer; however, most patients who receive ICB …

Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling mediates
almost all immune regulatory processes, including those that are involved in tumor cell …

Autophagy is a powerful tool that host cells use to defend against viral infection. Double-
membrane vesicles, termed autophagosomes, deliver trapped viral cargo to the lysosome …

The eponymous member of the interferon regulatory factor (IRF) family, IRF1, was originally
identified as a nuclear factor that binds and activates the promoters of type I interferon …

Cells maintain the balance between homeostasis and inflammation by adapting and
integrating the activity of intracellular signaling cascades, including the JAK-STAT pathway …

Through the study of transcriptional activation in response to interferon α (IFN-α) and
interferon γ (IFN-γ), a previously unrecognized direct signal transduction pathway to the …

Since its discovery two decades ago, the activation of the Janus kinase/signal transducers
and activators of transcription (JAK/STAT) pathway by numerous cytokines and growth …

Interferon regulatory factors (IRFs) constitute a family of transcription factors that commonly
possess a novel helix-turn-helix DNA-binding motif. Following the initial identification of two …

Abstract Interferon Regulatory Factors (IRFs), a family of transcription factors, profoundly
influence the immune system, impacting both physiological and pathological processes …

Acute-phase response factor (APRF) is a transcription factor that blnds to the Interfeukln-6
(IL-@-responsive elements identlfled In the promoters of various acutephase protein genes …