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Cell wall peptidoglycan in Mycobacterium tuberculosis: An Achilles' heel for the TB-causing pathogen
Tuberculosis (TB), caused by the intracellular pathogen Mycobacterium tuberculosis,
remains one of the leading causes of mortality across the world. There is an urgent …
remains one of the leading causes of mortality across the world. There is an urgent …
Tuberculosis drug discovery: A decade of hit assessment for defined targets
More than two decades have elapsed since the publication of the first genome sequence of
Mycobacterium tuberculosis (Mtb) which, shortly thereafter, enabled methods to determine …
Mycobacterium tuberculosis (Mtb) which, shortly thereafter, enabled methods to determine …
Exploring the interaction mechanism between potential inhibitor and multi-target Mur enzymes of mycobacterium tuberculosis using molecular docking, molecular …
Multi-targeting enzyme approaches are considered to be the most significant in suppressing
pathogen growth and disease control for MDR and XDR-resistant Mycobacterium …
pathogen growth and disease control for MDR and XDR-resistant Mycobacterium …
[HTML][HTML] An insight into the discovery, clinical studies, compositions, and patents of macozinone: A drug targeting the DprE1 enzyme of Mycobacterium tuberculosis
Abstract Decaprenyl-phosphoryl-ribose 2′-epimerase (DprE1) inhibitors are an innovative
and futuristic orally active group of antituberculosis agents. A few DprE1 inhibitors are in the …
and futuristic orally active group of antituberculosis agents. A few DprE1 inhibitors are in the …
Screening of natural compounds that targets glutamate racemase of Mycobacterium tuberculosis reveals the anti-tubercular potential of flavonoids
Tuberculosis (TB) is caused by Mycobacterium tuberculosis (MTB), a highly infectious
disease accounting for nearly 1.5 million deaths every year and has been a major global …
disease accounting for nearly 1.5 million deaths every year and has been a major global …
Ethambutol targets the glutamate racemase of Mycobacterium tuberculosis—an enzyme involved in peptidoglycan biosynthesis
Increasing drug resistance in pathogens including Mycobacterium tuberculosis (MTB) has
been ascribed to mutations in the known target genes. However, many of these drugs have …
been ascribed to mutations in the known target genes. However, many of these drugs have …
Moonlighting proteins: beacon of hope in era of drug resistance in bacteria
Moonlighting proteins (MLPs) are ubiquitous and provide a unique advantage to bacteria
performing multiple functions using the same genomic content. Targeting MLPs can be …
performing multiple functions using the same genomic content. Targeting MLPs can be …
Experimental evidence of d‐glutamate racemase activity in the uncultivated bacterium Candidatus Saccharimonas aalborgensis
Abstract The Candidate Phyla Radiation (CPR) encompasses widespread uncultivated
bacteria with reduced genomes and limited metabolic capacities. Most CPR bacteria lack …
bacteria with reduced genomes and limited metabolic capacities. Most CPR bacteria lack …
Glutamate Racemase Is the Primary Target of β-Chloro-d-Alanine in Mycobacterium tuberculosis
The increasing global prevalence of drug resistance among many leading human
pathogens necessitates both the development of antibiotics with novel mechanisms of action …
pathogens necessitates both the development of antibiotics with novel mechanisms of action …
Identification and development of benzoxazole derivatives as novel bacterial glutamate racemase inhibitors
In the present study, we attempted to develop novel class of Mycobacterium tuberculosis
(Mtb) inhibitors by exploring the pharmaceutically underexploited enzyme targets which are …
(Mtb) inhibitors by exploring the pharmaceutically underexploited enzyme targets which are …