Drug repurposing for antimicrobial discovery

MA Farha, ED Brown - Nature microbiology, 2019 - nature.com
Antimicrobial resistance continues to be a public threat on a global scale. The ongoing need
to develop new antimicrobial drugs that are effective against multi-drug-resistant pathogens …

Drugs targeting various stages of the SARS-CoV-2 life cycle: Exploring promising drugs for the treatment of Covid-19

R Poduri, G Joshi, G Jagadeesh - Cellular signalling, 2020 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense,
single-stranded RNA virus that causes the potentially lethal Covid-19 respiratory tract …

[HTML][HTML] Targeting OXPHOS and the electron transport chain in cancer; Molecular and therapeutic implications

J Greene, A Segaran, S Lord - Seminars in Cancer Biology, 2022 - Elsevier
Oxidative phosphorylation (OXPHOS) takes place in mitochondria and is the process
whereby cells use carbon fuels and oxygen to generate ATP. Formerly OXPHOS was …

[HTML][HTML] Drug repurposing and human parasitic protozoan diseases

KT Andrews, G Fisher, TS Skinner-Adams - International Journal for …, 2014 - Elsevier
Parasitic diseases have an enormous health, social and economic impact and are a
particular problem in tropical regions of the world. Diseases caused by protozoa and …

Doxycycline prophylaxis for bacterial sexually transmitted infections

JS Grant, C Stafylis, C Celum, T Grennan… - Clinical Infectious …, 2020 - academic.oup.com
Bacterial sexually transmitted infections (STIs) have been increasing over the past 2
decades in gay, bisexual, and other men who have sex with men. With the widespread use …

Revisiting doxycycline in pregnancy and early childhood–time to rebuild its reputation?

R Cross, C Ling, NPJ Day, R McGready… - Expert opinion on drug …, 2016 - Taylor & Francis
Introduction: Doxycycline is highly effective, inexpensive with a broad therapeutic spectrum
and exceptional bioavailability. However these benefits have been overshadowed by its …

Moxidectin: an oral treatment for human onchocerciasis

P Milton, JID Hamley, M Walker… - Expert Review of Anti …, 2020 - Taylor & Francis
Introduction Moxidectin is a milbemycin endectocide recently approved for the treatment of
human onchocerciasis. Onchocerciasis, earmarked for elimination of transmission, is a …

Antibiotics in ingested human blood affect the mosquito microbiota and capacity to transmit malaria

M Gendrin, FH Rodgers, RS Yerbanga… - Nature …, 2015 - nature.com
Malaria reduction is most efficiently achieved by vector control whereby human populations
at high risk of contracting and transmitting the disease are protected from mosquito bites …

Comprehensive review on various strategies for antimalarial drug discovery

M Mishra, VK Mishra, V Kashaw, AK Iyer… - European journal of …, 2017 - Elsevier
The resistance of malaria parasites to existing drugs carries on growing and progressively
limiting our ability to manage this severe disease and finally lead to a massive global health …

Tetracyclines in malaria

T Gaillard, M Madamet, B Pradines - Malaria journal, 2015 - Springer
Malaria, a parasite vector-borne disease, is one of the greatest health threats in tropical
regions, despite the availability of malaria chemoprophylaxis. The emergence and rapid …