The present review offers an overview of nonclassical (eg, with no pre-or in situ activation of
a carboxylic acid partner) approaches for the construction of amide bonds. The review aims …

The amide functionality is found in a wide variety of biological and synthetic structures such
as proteins, polymers, pesticides and pharmaceuticals. Due to the fact that synthetic amides …

Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals |
Organic Process Research & Development ACS ACS Publications C&EN CAS Find my …

This review describes the practical aspects involved in the implementation of large-scale
amidations in process chemistry. Coupling reagent, base, additive, and solvent selections …

Although boronic acids are recognized primarily for their utility as reagents in transition
metal-catalyzed transformations, other applications are emerging, including their use as …

The synthesis of amides is of huge importance in a wide variety of industrial and academic
fields and is of particular significance in the synthesis of pharmaceuticals. Many of the well …

Amide bond forming reactions are critical for both polypeptide synthesis and medicinal
chemistry. Most current approaches for amidation employ stoichiometric activating agents …

B (OCH2CF3) 3, prepared from readily available B2O3 and 2, 2, 2-trifluoroethanol, is as an
effective reagent for the direct amidation of a variety of carboxylic acids with a broad range of …

Chemical reactions for the formation of amide bonds are among the most commonly used
transformations in organic chemistry, yet they are often highly inefficient. A novel protocol for …

The expansion of molecular diversity beyond what nature can produce is a fundamental
objective in chemical sciences. Despite the rich chemistry of boron-containing heterocycles …