Bacterial persisters: molecular mechanisms and therapeutic development

H Niu, J Gu, Y Zhang - Signal transduction and targeted therapy, 2024 - nature.com
Persisters refer to genetically drug susceptible quiescent (non-growing or slow growing)
bacteria that survive in stress environments such as antibiotic exposure, acidic and …

Gut microbiota-derived tryptophan metabolites maintain gut and systemic homeostasis

X Su, Y Gao, R Yang - Cells, 2022 - mdpi.com
Tryptophan is an essential amino acid from dietary proteins. It can be metabolized into
different metabolites in both the gut microbiota and tissue cells. Tryptophan metabolites such …

Dietary fibre directs microbial tryptophan metabolism via metabolic interactions in the gut microbiota

AK Sinha, MF Laursen, JE Brinck, ML Rybtke… - Nature …, 2024 - nature.com
Tryptophan is catabolized by gut microorganisms resulting in a wide range of metabolites
implicated in both beneficial and adverse host effects. How gut microbial tryptophan …

[HTML][HTML] The gut microbiota contributes to the pathogenesis of anorexia nervosa in humans and mice

Y Fan, RK Støving, S Berreira Ibraim… - Nature …, 2023 - nature.com
Anorexia nervosa (AN) is an eating disorder with a high mortality. About 95% of cases are
women and it has a population prevalence of about 1%, but evidence-based treatment is …

Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases

W Yang, Y Cong - Cellular & molecular immunology, 2021 - nature.com
The gut microbiota has a critical role in the maintenance of immune homeostasis. Alterations
in the intestinal microbiota and gut microbiota-derived metabolites have been recognized in …

Diet–microbiota interactions and personalized nutrition

AA Kolodziejczyk, D Zheng, E Elinav - Nature Reviews Microbiology, 2019 - nature.com
Conceptual scientific and medical advances have led to a recent realization that there may
be no single, one-size-fits-all diet and that differential human responses to dietary inputs …

Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond

M Platten, EAA Nollen, UF Röhrig, F Fallarino… - Nature reviews Drug …, 2019 - nature.com
Abstract l-Tryptophan (Trp) metabolism through the kynurenine pathway (KP) is involved in
the regulation of immunity, neuronal function and intestinal homeostasis. Imbalances in Trp …

Microbial tryptophan catabolites in health and disease

HM Roager, TR Licht - Nature communications, 2018 - nature.com
Accumulating evidence implicates metabolites produced by gut microbes as crucial
mediators of diet-induced host-microbial cross-talk. Here, we review emerging data …

[HTML][HTML] Tryptophan metabolism: a link between the gut microbiota and brain

K Gao, C Mu, A Farzi, W Zhu - Advances in Nutrition, 2020 - Elsevier
The gut-brain axis (GBA) is a bilateral communication network between the gastrointestinal
(GI) tract and the central nervous system. The essential amino acid tryptophan contributes to …

Dual role of indoles derived from intestinal microbiota on human health

X Ye, H Li, K Anjum, X Zhong, S Miao, G Zheng… - Frontiers in …, 2022 - frontiersin.org
Endogenous indole and its derivatives (indoles), considered as promising N-substituted
heterocyclic compounds, are tryptophan metabolites derived from intestinal microbiota and …