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Bacterial persisters: molecular mechanisms and therapeutic development
H Niu, J Gu, Y Zhang - Signal transduction and targeted therapy, 2024 - nature.com
Persisters refer to genetically drug susceptible quiescent (non-growing or slow growing)
bacteria that survive in stress environments such as antibiotic exposure, acidic and …
bacteria that survive in stress environments such as antibiotic exposure, acidic and …
Gut microbiota-derived tryptophan metabolites maintain gut and systemic homeostasis
X Su, Y Gao, R Yang - Cells, 2022 - mdpi.com
Tryptophan is an essential amino acid from dietary proteins. It can be metabolized into
different metabolites in both the gut microbiota and tissue cells. Tryptophan metabolites such …
different metabolites in both the gut microbiota and tissue cells. Tryptophan metabolites such …
Dietary fibre directs microbial tryptophan metabolism via metabolic interactions in the gut microbiota
Tryptophan is catabolized by gut microorganisms resulting in a wide range of metabolites
implicated in both beneficial and adverse host effects. How gut microbial tryptophan …
implicated in both beneficial and adverse host effects. How gut microbial tryptophan …
[HTML][HTML] The gut microbiota contributes to the pathogenesis of anorexia nervosa in humans and mice
Anorexia nervosa (AN) is an eating disorder with a high mortality. About 95% of cases are
women and it has a population prevalence of about 1%, but evidence-based treatment is …
women and it has a population prevalence of about 1%, but evidence-based treatment is …
Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases
The gut microbiota has a critical role in the maintenance of immune homeostasis. Alterations
in the intestinal microbiota and gut microbiota-derived metabolites have been recognized in …
in the intestinal microbiota and gut microbiota-derived metabolites have been recognized in …
Diet–microbiota interactions and personalized nutrition
Conceptual scientific and medical advances have led to a recent realization that there may
be no single, one-size-fits-all diet and that differential human responses to dietary inputs …
be no single, one-size-fits-all diet and that differential human responses to dietary inputs …
Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond
Abstract l-Tryptophan (Trp) metabolism through the kynurenine pathway (KP) is involved in
the regulation of immunity, neuronal function and intestinal homeostasis. Imbalances in Trp …
the regulation of immunity, neuronal function and intestinal homeostasis. Imbalances in Trp …
Microbial tryptophan catabolites in health and disease
Accumulating evidence implicates metabolites produced by gut microbes as crucial
mediators of diet-induced host-microbial cross-talk. Here, we review emerging data …
mediators of diet-induced host-microbial cross-talk. Here, we review emerging data …
[HTML][HTML] Tryptophan metabolism: a link between the gut microbiota and brain
The gut-brain axis (GBA) is a bilateral communication network between the gastrointestinal
(GI) tract and the central nervous system. The essential amino acid tryptophan contributes to …
(GI) tract and the central nervous system. The essential amino acid tryptophan contributes to …
Dual role of indoles derived from intestinal microbiota on human health
X Ye, H Li, K Anjum, X Zhong, S Miao, G Zheng… - Frontiers in …, 2022 - frontiersin.org
Endogenous indole and its derivatives (indoles), considered as promising N-substituted
heterocyclic compounds, are tryptophan metabolites derived from intestinal microbiota and …
heterocyclic compounds, are tryptophan metabolites derived from intestinal microbiota and …