Executive summary Every infant, child, and adolescent will experience pain at times
throughout their life. Childhood pain ranges from acute to chronic, and includes procedural …

Polypharmacy is commonly employed in clinical settings. The potential risks of drug–drug
interactions (DDIs) can compromise efficacy and pose serious health hazards. Integrating …

Background Acute pain is a common symptom in children of all ages, and is associated with
a variety of conditions. Despite the availability of guidelines, pain often remains …

Abstract Background and Objective Combined acetaminophen and ibuprofen are common
antipyretic and analgesic drugs. Formulation and feeding affect drug absorption. Drug …

Background Ibuprofen is widely used for ductus arteriosus closure in premature neonates
and for analgesia in children and adults. There are no maturation descriptors of clearance …

This is the second of a two-part series reviewing the perioperative care of a child undergoing
elective adenotonsillectomy (AT) to treat either obstructive sleep-disordered breathing …

Acetaminophen is a commonly used perioperative analgesic drug in children. The use of a
preoperative loading dose achieves a target concentration of 10 mg/L associated with a …

Background and objectives: The combination of non-steroidal anti-inflammatory drugs and
paracetamol is widely used for pediatric postoperative pain management, although the …

Background Pain following tonsillectomy is often poorly managed in the home setting.
Multimodal analgesia with acetaminophen (paracetamol) and nonsteroidal anti …

Pharmacokinetic pharmacodynamic modeling is an important tool which uses statistical
methodology to provide a better understanding of the relationship between concentration …