Mechanisms of Resistance to Immunotoxins Containing Pseudomonas Exotoxin A in Cancer Therapy

M Dieffenbach, I Pastan - Biomolecules, 2020 - mdpi.com
Immunotoxins are a class of targeted cancer therapeutics in which a toxin such as
Pseudomonas exotoxin A (PE) is linked to an antibody or cytokine to direct the toxin to a …

Mechanism of exportin retention in the cell nucleus

LE Kapinos, J Kalita, E Kassianidou, C Rencurel… - Journal of Cell …, 2024 - rupress.org
Exportin receptors are concentrated in the nucleus to transport essential cargoes out of it. A
mislocalization of exportins to the cytoplasm is linked to disease. Hence, it is important to …

TRAIL mediates and sustains constitutive NF-κB activation in LGL leukemia

J Yang, FR LeBlanc, SA Dighe… - Blood, The Journal …, 2018 - ashpublications.org
Large granular lymphocyte (LGL) leukemia results from clonal expansion of CD3+ cytotoxic
T lymphocytes or CD3− natural killer (NK) cells. Chronic antigen stimulation is postulated to …

[HTML][HTML] Esculetin inhibits proliferation, invasion, and migration of laryngeal cancer in vitro and in vivo by inhibiting Janus kinas (JAK)-signal transducer and activator of …

G Zhang, Y Xu, H Zhou - Medical science monitor: international …, 2019 - ncbi.nlm.nih.gov
Background Laryngeal cancer is one of the most common malignant tumors of the head and
neck. Natural compounds in traditional Chinese medicine provide many valuable potential …

A multi-target protein of hTERTR-FAM96A presents significant anticancer potent in the treatment of hepatocellular carcinoma

MY Zhang, JP Wang - Tumor Biology, 2017 - journals.sagepub.com
The abilities to escape apoptosis induced by anticancer drugs are an essential factor of
carcinogenesis and a hallmark of resistance to cancer therapy. In this study, we identified …

Icotinib inhibits the proliferation of hepatocellular carcinoma cells in vitro and in vivo dependently on EGFR activation and PDL1 expression

J Sun, W Jiang, D Tian, Q Guo, Z Shen - OncoTargets and therapy, 2018 - Taylor & Francis
Purpose Hepatocellular carcinoma (HCC) accounts for one of the most prevalent tumor
types in the world and still lacks an effective treatment regimen. The EGFR tyrosine-kinase …

Cellular apoptosis susceptibility protein (CAS) suppresses the proliferation of breast cancer cells by upregulated cyp24a1

M Ye, R Han, J Shi, X Wang, AZ Zhao, F Li, H Chen - Medical Oncology, 2020 - Springer
Breast cancer is the most common cancer in women. Although several studies demonstrated
cellular apoptosis susceptibility protein (CAS) involved in the development of breast cancer …

Aberrant localization of signaling proteins in skin cancer: Implications for treatment

TR Holmes, S Dindu, LA Hansen - Molecular Carcinogenesis, 2019 - Wiley Online Library
Aberrant subcellular localization of signaling proteins can provide cancer cells with
advantages such as resistance to apoptotic cell death, increased invasiveness and more …

Differential activation of CD95-mediated apoptosis related proteins in proximal and distal tubules during rat renal development

XF Song, H Tian, ZX Zhang - Tissue and Cell, 2016 - Elsevier
The CD95-mediated apoptotic pathway is the best characterized of the death receptor-
mediated apoptotic pathways. The present study characterized localization and expression …

[CITATION][C] TRAIL Mediates and Sustains Constitutive NF-κB Activation in LGL Leukemia Running Title: TRAIL activates NF-κB in LGL Leukemia

J Yang, FR LeBlanc, SA Dighe, CE Hamele, TL Olson… - 2018