Understanding emotions: origins and roles of the amygdala
Emotions arise from activations of specialized neuronal populations in several parts of the
cerebral cortex, notably the anterior cingulate, insula, ventromedial prefrontal, and …
cerebral cortex, notably the anterior cingulate, insula, ventromedial prefrontal, and …
Integration of optogenetics with complementary methodologies in systems neuroscience
Modern optogenetics can be tuned to evoke activity that corresponds to naturally occurring
local or global activity in timing, magnitude or individual-cell patterning. This outcome has …
local or global activity in timing, magnitude or individual-cell patterning. This outcome has …
Obesity-induced cellular senescence drives anxiety and impairs neurogenesis
Cellular senescence entails a stable cell-cycle arrest and a pro-inflammatory secretory
phenotype, which contributes to aging and age-related diseases. Obesity is associated with …
phenotype, which contributes to aging and age-related diseases. Obesity is associated with …
Identification of a prefrontal cortex-to-amygdala pathway for chronic stress-induced anxiety
WZ Liu, WH Zhang, ZH Zheng, JX Zou, XX Liu… - Nature …, 2020 - nature.com
Dysregulated prefrontal control over amygdala is engaged in the pathogenesis of psychiatric
diseases including depression and anxiety disorders. Here we show that, in a rodent anxiety …
diseases including depression and anxiety disorders. Here we show that, in a rodent anxiety …
[HTML][HTML] Anxiety cells in a hippocampal-hypothalamic circuit
The hippocampus is traditionally thought to transmit contextual information to limbic
structures where it acquires valence. Using freely moving calcium imaging and …
structures where it acquires valence. Using freely moving calcium imaging and …
Fear balance is maintained by bodily feedback to the insular cortex in mice
How does the brain maintain fear within an adaptive range? We found that the insular cortex
acts as a state-dependent regulator of fear that is necessary to establish an equilibrium …
acts as a state-dependent regulator of fear that is necessary to establish an equilibrium …
Prefrontal cortex circuits in depression and anxiety: contribution of discrete neuronal populations and target regions
Our understanding of depression and its treatment has advanced with the advent of
ketamine as a rapid-acting antidepressant and the development and refinement of tools …
ketamine as a rapid-acting antidepressant and the development and refinement of tools …
Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications
CC Jiang, LS Lin, S Long, XY Ke, K Fukunaga… - Signal transduction and …, 2022 - nature.com
Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …
Midbrain projection to the basolateral amygdala encodes anxiety-like but not depression-like behaviors
Anxiety disorders are complex diseases, and often co-occur with depression. It is as yet
unclear if a common neural circuit controls anxiety-related behaviors in both anxiety-alone …
unclear if a common neural circuit controls anxiety-related behaviors in both anxiety-alone …
Behavioral and neurobiological mechanisms of pavlovian and instrumental extinction learning
This article reviews the behavioral neuroscience of extinction, the phenomenon in which a
behavior that has been acquired through Pavlovian or instrumental (operant) learning …
behavior that has been acquired through Pavlovian or instrumental (operant) learning …