Artificial intelligence and machine learning technology driven modern drug discovery and development

C Sarkar, B Das, VS Rawat, JB Wahlang… - International Journal of …, 2023 - mdpi.com
The discovery and advances of medicines may be considered as the ultimate relevant
translational science effort that adds to human invulnerability and happiness. But advancing …

Machine learning in drug discovery: a review

S Dara, S Dhamercherla, SS Jadav, CHM Babu… - Artificial intelligence …, 2022 - Springer
This review provides the feasible literature on drug discovery through ML tools and
techniques that are enforced in every phase of drug development to accelerate the research …

Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials

MC Lampi, CA Reinhart-King - Science translational medicine, 2018 - science.org
Tissues stiffen during aging and during the pathological progression of cancer, fibrosis, and
cardiovascular disease. Extracellular matrix stiffness is emerging as a prominent mechanical …

Artificial intelligence in drug design

F Zhong, J **ng, X Li, X Liu, Z Fu, Z **ong, D Lu… - Science China Life …, 2018 - Springer
Thanks to the fast improvement of the computing power and the rapid development of the
computational chemistry and biology, the computer-aided drug design techniques have …

Targeting CPT1A-mediated fatty acid oxidation sensitizes nasopharyngeal carcinoma to radiation therapy

Z Tan, L **ao, M Tang, F Bai, J Li, L Li, F Shi… - …, 2018 - pmc.ncbi.nlm.nih.gov
Nasopharyngeal carcinoma (NPC) has a particularly high prevalence in southern China,
southeastern Asia and northern Africa. Radiation resistance remains a serious obstacle to …

Natural product synthesis in the 21st century: Beyond the mountain top

RA Shenvi - ACS Central Science, 2024 - ACS Publications
Research into natural products emerged from humanity's curiosity about the nature of matter
and its role in the materia medica of diverse civilizations. Plants and fungi, in particular …

Targeting Epstein-Barr virus in nasopharyngeal carcinoma

PM Hau, HL Lung, M Wu, CM Tsang, KL Wong… - Frontiers in …, 2020 - frontiersin.org
Nasopharyngeal carcinoma (NPC) is consistently associated with Epstein-Barr virus (EBV)
infection in regions in which it is endemic, including Southern China and Southeast Asia …

Artificial intelligence (AI) in drugs and pharmaceuticals

A Sahu, J Mishra, N Kushwaha - Combinatorial chemistry & high …, 2022 - benthamdirect.com
The advancement of computing and technology has invaded all the dimensions of science.
Artificial intelligence (AI) is one core branch of Computer Science, which has percolated to …

Identifying hydrophobic protein patches to inform protein interaction interfaces

NB Rego, E **, AJ Patel - Proceedings of the National Academy of …, 2021 - pnas.org
Interactions between proteins lie at the heart of numerous biological processes and are
essential for the proper functioning of the cell. Although the importance of hydrophobic …

Deciphering the lexicon of protein targets: a review on multifaceted drug discovery in the era of artificial intelligence

S Nandi, S Bhaduri, D Das, P Ghosh… - Molecular …, 2024 - ACS Publications
Understanding protein sequence and structure is essential for understanding protein–
protein interactions (PPIs), which are essential for many biological processes and diseases …