Interpretation of the evidence for the efficacy and safety of statin therapy
This Review is intended to help clinicians, patients, and the public make informed decisions
about statin therapy for the prevention of heart attacks and strokes. It explains how the …
about statin therapy for the prevention of heart attacks and strokes. It explains how the …
Associations between statins and adverse events in primary prevention of cardiovascular disease: systematic review with pairwise, network, and dose-response meta …
Objective To assess the associations between statins and adverse events in primary
prevention of cardiovascular disease and to examine how the associations vary by type and …
prevention of cardiovascular disease and to examine how the associations vary by type and …
[HTML][HTML] Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials
Background Statin therapy is effective for the prevention of atherosclerotic cardiovascular
disease and is widely prescribed, but there are persisting concerns that statin therapy might …
disease and is widely prescribed, but there are persisting concerns that statin therapy might …
Why most clinical research is not useful
JPA Ioannidis - PLoS medicine, 2016 - journals.plos.org
Why Most Clinical Research Is Not Useful | PLOS Medicine Skip to main content
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Primary prevention of cardiovascular disease: A review of contemporary guidance and literature
J Stewart, G Manmathan… - JRSM cardiovascular …, 2017 - journals.sagepub.com
Cardiovascular disease is a significant and ever-growing problem in the United Kingdom,
accounting for nearly one-third of all deaths and leading to significant morbidity. It is also of …
accounting for nearly one-third of all deaths and leading to significant morbidity. It is also of …
Statin treatment and muscle symptoms: series of randomised, placebo controlled n-of-1 trials
E Herrett, E Williamson, K Brack, D Beaumont… - bmj, 2021 - bmj.com
Objective To establish the effect of statins on muscle symptoms in people who had
previously reported muscle symptoms when taking statins. Design Series of randomised …
previously reported muscle symptoms when taking statins. Design Series of randomised …
Adverse events associated with unblinded, but not with blinded, statin therapy in the Anglo-Scandinavian Cardiac Outcomes Trial—Lipid-Lowering Arm (ASCOT-LLA) …
A Gupta, D Thompson, A Whitehouse, T Collier… - The Lancet, 2017 - thelancet.com
Background In blinded randomised controlled trials, statin therapy has been associated with
few adverse events (AEs). By contrast, in observational studies, larger increases in many …
few adverse events (AEs). By contrast, in observational studies, larger increases in many …
Misrepresentation and distortion of research in biomedical literature
I Boutron, P Ravaud - … of the National Academy of Sciences, 2018 - National Acad Sciences
Publication in peer-reviewed journals is an essential step in the scientific process. However,
publication is not simply the reporting of facts arising from a straightforward analysis thereof …
publication is not simply the reporting of facts arising from a straightforward analysis thereof …
[PDF][PDF] 2016 European Guidelines on cardiovascular disease prevention in clinical practice
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. 840 2.4. 1. Wywiad rodzinny/(epi) genetyka............ 840 2.4. 1.1. Wywiad …
. 840 2.4. 1. Wywiad rodzinny/(epi) genetyka............ 840 2.4. 1.1. Wywiad …
High-sensitivity cardiac troponin, statin therapy, and risk of coronary heart disease
Background: Cardiac troponin is an independent predictor of cardiovascular mortality in
individuals without symptoms or signs of cardiovascular disease. The mechanisms for this …
individuals without symptoms or signs of cardiovascular disease. The mechanisms for this …