Cardiovascular disease (CVD) is a serious health challenge, causing more deaths
worldwide than cancer. The vascular endothelium, which forms the inner lining of blood …

Vascular endothelial cells (ECs) are exposed to hemodynamic forces, which modulate EC
functions and vascular biology/pathobiology in health and disease. The flow patterns and …

Abstract The Yorkie homologues YAP (Yes-associated protein) and TAZ (transcriptional
coactivator with PDZ-binding motif, also known as WWTR1), effectors of the Hippo pathway …

Atherosclerotic vascular disease and its complications are among the top causes of mortality
worldwide. In the vascular lumen, atherosclerotic plaques are not randomly distributed …

EC activation and dysfunction have been linked to a variety of vascular inflammatory
disease states. The function of microRNAs (miRNAs) in vascular EC activation and …

Severe sepsis, defined as sepsis with acute organ dysfunction, is associated with high
morbidity and mortality rates. The development of novel therapies for sepsis is critically …

Blood vessels are constantly exposed to hemodynamic forces in the form of cyclic stretch
and shear stress due to the pulsatile nature of blood pressure and flow. Endothelial cells …

Atherosclerosis is the main cause of morbidity and mortality in the Western world.
Inflammation and blood flow alterations are new markers emerging as possible …

Endothelial and smooth muscle cells of the vasculature are equipped with numerous
receptors that allow them to detect and react to subtle changes in their physical environment …

It is well accepted that atherosclerosis occurs in a site-specific manner especially at branch
points where disturbed blood flow (d-flow) predisposes to the development of plaques …