Protozoan Kinetoplastida, including the pathogenic trypanosomatids of the genera
Trypanosoma and Leishmania, compartmentalize several important metabolic systems in …

Triosephosphate isomerase (TIM) is a perfectly evolved enzyme which very fast
interconverts dihydroxyacetone phosphate and d-glyceraldehyde-3-phosphate. Its catalytic …

JWS Online is a repository of kinetic models, describing biological systems, which can be
interactively run and interrogated over the Internet. It is implemented using a client–server …

Glycolysis is perceived as a promising target for new drugs against parasitic trypanosomatid
protozoa because this pathway plays an essential role in their ATP supply. Trypanosomatid …

Peroxisomes of organisms belonging to the protist group Kinetoplastea, which include
trypanosomatid parasites of the genera Trypanosoma and Leishmania, are unique in …

Survival of bloodstream form Trypanosoma brucei, the agent of African slee** sickness,
normally requires mitochondrial gene expression, despite the absence of oxidative …

Trypanosome alternative oxidase (TAO) is the cytochrome-independent terminal oxidase of
the mitochondrial electron transport chain. TAO is a diiron protein that transfers electrons …

Kinetoplastida are protozoan organisms that probably diverged early in evolution from other
eukaryotes. They are characterized by a number of unique features with respect to their …

The human pathogenic trypanosomatid species collectively called the “TriTryp parasites”–
Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp.–have complex life cycles …

Salivarian trypanosomes are the causative agents of several diseases of major social and
economic impact. The most infamous parasites of this group are the African subspecies of …