Applications of acoustics and cavitation to noninvasive therapy and drug delivery

CC Coussios, RA Roy - Annu. Rev. Fluid Mech., 2008 - annualreviews.org
Biomedical acoustics is rapidly evolving from a diagnostic modality into a therapeutic tool,
and acoustic cavitation is often the common denominator in a wide range of new therapeutic …

[HTML][HTML] Mechanisms underlying sonoporation: Interaction between microbubbles and cells

Y Yang, Q Li, X Guo, J Tu, D Zhang - Ultrasonics Sonochemistry, 2020 - Elsevier
The past several decades have witnessed great progress in “smart drug delivery”, an
advance technology that can deliver genes or drugs into specific locations of patients' body …

[HTML][HTML] Ultrasound-mediated drug delivery: sonoporation mechanisms, biophysics, and critical factors

CH YuAlfred - BME frontiers, 2022 - spj.science.org
Sonoporation, or the use of ultrasound in the presence of cavitation nuclei to induce plasma
membrane perforation, is well considered as an emerging physical approach to facilitate the …

In vivo transcranial cavitation threshold detection during ultrasound-induced blood–brain barrier opening in mice

YS Tung, F Vlachos, JJ Choi, T Deffieux… - Physics in Medicine …, 2010 - iopscience.iop.org
The in vivo cavitation response associated with blood–brain barrier (BBB) opening as
induced by transcranial focused ultrasound (FUS) in conjunction with microbubbles was …

Potential and problems in ultrasound-responsive drug delivery systems

YZ Zhao, LN Du, CT Lu, YG **… - International journal of …, 2013 - Taylor & Francis
Ultrasound is an important local stimulus for triggering drug release at the target tissue.
Ultrasound-responsive drug delivery systems (URDDS) have become an important research …

An in vitro study of a phase-shift nanoemulsion: a potential nucleation agent for bubble-enhanced HIFU tumor ablation

P Zhang, T Porter - Ultrasound in medicine & biology, 2010 - Elsevier
Phase-shift nanoemulsions have the potential to nucleate bubbles and enhance high-
intensity focused ultrasound (HIFU) cancer therapy. This emulsion consists of albumin …

[HTML][HTML] Efficient sonochemical catalytic degradation of tetracycline using TiO2 fractured nanoshells

Z Zong, E Gilbert, CCY Wong, L Usadi, Y Qin… - Ultrasonics …, 2023 - Elsevier
Overexposure to antibiotics originating in wastewater has profound environmental and
health implications. Conventional treatment methods are not fully effective in removing …

Ultrasonic synthesis of stable, functional lysozyme microbubbles

F Cavalieri, M Ashokkumar, F Grieser, F Caruso - Langmuir, 2008 - ACS Publications
High-intensity ultrasound induces emulsification and cross-linking of protein molecules in
aqueous medium. The stability and the functionality of the resultant protein-coated …

A study of bubble activity generated in ex vivo tissue by high intensity focused ultrasound

J McLaughlan, I Rivens, T Leighton… - Ultrasound in medicine & …, 2010 - Elsevier
Cancer treatment by extracorporeal high-intensity focused ultrasound (HIFU) is constrained
by the time required to ablate clinically relevant tumour volumes. Although cavitation may be …

Properties, characteristics and applications of microbubbles for sonothrombolysis

M de Saint Victor, C Crake, CC Coussios… - Expert opinion on drug …, 2014 - Taylor & Francis
Introduction: Ultrasound enhancement of thrombolysis (sonothrombolysis) is further
potentiated by administration of acoustically active microbubbles, which may be developed …