One hundred years have passed since Warburg discovered alterations in cancer
metabolism, more than 70 years since Sidney Farber introduced anti-folates that …

Metabolic reprogramming in cancer is not only a biological hallmark but also reveals
treatment vulnerabilities. Numerous metabolic molecules have shown promise as treatment …

The integration of mass spectrometry-based proteomics with next-generation DNA and RNA
sequencing profiles tumors more comprehensively. Here this" proteogenomics" approach …

Metabolic changes contribute to cancer initiation and progression through effects on cancer
cells, the tumor microenvironment and whole-body metabolism. Alterations in serine …

Cancer cells reprogramme their metabolism to support unrestrained proliferation and
survival in nutrient-poor conditions. Whereas non-transformed cells often have lower …

Chiral amides are important structure in many natural products and pharmaceuticals, yet
their efficient synthesis from simple amide feedstock remains challenge due to its weak …

The serine-glycine-one-carbon (SGOC) metabolic pathway is critical for DNA methylation,
histone methylation, and redox homeostasis, in addition to protein, lipid, and nucleotide …

Enzymes are common targets in high-throughput screening and related campaigns. An
analysis of papers published between 1990 and 2018 showed that kinases were the most …

The multifunctional roles of metabolic enzymes allow for the integration of multiple signals to
precisely transduce external stimuli into cell fate decisions. Elevation of 3-phosphoglycerate …

Serine, a non-essential amino acid, can be imported from the extracellular environment by
transporters and de novo synthesized from glycolytic 3-phosphoglycerate (3-PG) in the …