Sarcopenia in the older adult with cancer

GR Williams, RF Dunne, S Giri… - Journal of Clinical …, 2021 - pmc.ncbi.nlm.nih.gov
The term sarcopenia, derived from the Greek words sarx for flesh and penia for loss, was first
introduced by Rosenberg 1 in 1989 to describe the loss of muscle mass that accompanies …

[HTML][HTML] Forcing the vicious circle: sarcopenia increases toxicity, decreases response to chemotherapy and worsens with chemotherapy

F Bozzetti - Annals of oncology, 2017 - Elsevier
Sarcopenia has recently emerged as a new condition that, independently from malnutrition,
may adversely affect the prognosis of cancer patients. Purpose of this narrative review is to …

Tumor-derived IL-6 and trans-signaling among tumor, fat, and muscle mediate pancreatic cancer cachexia

JE Rupert, A Narasimhan, DHA Jengelley… - Journal of Experimental …, 2021 - rupress.org
Most patients with pancreatic adenocarcinoma (PDAC) suffer cachexia; some do not. To
model heterogeneity, we used patient-derived orthotopic xenografts. These phenocopied …

Effects of weight loss and sarcopenia on response to chemotherapy, quality of life, and survival

AM Ryan, CM Prado, ES Sullivan, DG Power, LE Daly - Nutrition, 2019 - Elsevier
It has frequently been shown that patients with cancer are one of the largest hospital patient
groups with a prevalence for malnutrition. Weight loss is a frequent manifestation of …

Diffuse large B-cell lymphoma: R-CHOP failure—what to do?

B Coiffier, C Sarkozy - Hematology 2014, the American Society …, 2016 - ashpublications.org
Although rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-
CHOP) is the standard treatment for patients with diffuse large B-cell lymphoma (DLBCL),∼ …

Computed tomography-defined muscle and fat wasting are associated with cancer clinical outcomes

SMR Kazemi-Bajestani, VC Mazurak… - Seminars in cell & …, 2016 - Elsevier
Cancer cachexia (ie, skeletal muscle wasting with or without fat loss) relates to several
adverse outcomes. Computed tomography (CT) cross-sectional images serve as an efficient …

Prevalence and prognostic impact of cachexia among older patients with cancer: a nationwide cross‐sectional survey (NutriAgeCancer)

J Poisson, C Martinez‐Tapia, D Heitz… - Journal of cachexia …, 2021 - Wiley Online Library
Background Nutritional impairment is common in cancer patients and is associated with
poor outcomes. Only few studies focused on cachexia. We assessed the prevalence of …

The prevalence and prognostic value of low muscle mass in cancer patients: a review of the literature

HN Rier, A Jager, S Sleijfer, AB Maier… - The oncologist, 2016 - academic.oup.com
In several diseases, low muscle mass has been revealed as an unfavorable prognostic
factor for outcome. Whether this holds true in patients with solid malignancies as well has …

[HTML][HTML] Cachexia and sarcopenia in older adults with cancer: a comprehensive review

RF Dunne, KP Loh, GR Williams, A Jatoi, KM Mustian… - Cancers, 2019 - mdpi.com
Cancer cachexia is a syndrome characterized by weight loss with accompanying loss of
muscle and/or fat mass and leads to impaired patient function and physical performance and …

Body composition and sarcopenia: the next-generation of personalized oncology and pharmacology?

M Hilmi, A Jouinot, R Burns, F Pigneur… - Pharmacology & …, 2019 - Elsevier
Body composition has gained increasing attention in oncology in recent years due to fact
that sarcopenia has been revealed to be a strong prognostic indicator for survival across …