The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

Here we focus on how neutrophils have a key regulatory role in vascular inflammation.
Recent studies using advanced imaging techniques have yielded new insights into the …

Both the innate and adaptive immune responses are dependent on the migration of
leukocytes across endothelial cells. The process of diapedesis, in which the leukocyte …

In vivo, leukocyte transendothelial migration (TEM) occurs at endothelial cell junctions
(paracellular) and nonjunctional (transcellular) locations, whereas in vitro models report that …

A central function of the vascular endothelium is to serve as a barrier between the blood and
the surrounding tissue of the body. At the same time, solutes and cells have to pass the …

The migration of neutrophils into inflamed tissues is a fundamental component of innate
immunity. A decisive step in this process is the polarized migration of blood neutrophils …

Disruption of the tight junctions (TJs) of the blood–brain barrier (BBB) is a hallmark of many
CNS pathologies, including stroke, HIV encephalitis, Alzheimer's disease, multiple sclerosis …

The prevailing view is that the β2-integrins Mac-1 (αMβ2, CD11b/CD18) and LFA-1 (αLβ2,
CD11a/CD18) serve similar biological functions, namely adhesion, in the leukocyte …

Damage to the central nervous system (CNS) leads to cellular changes not only in the
affected neurons but also in adjacent glial cells and endothelia, and frequently, to a …

The acute respiratory distress syndrome (ARDS) is a life-threatening lung condition resulting
from direct and indirect insults to the lung. It is characterized by disruption of the endothelial …