Immunoglobulins (Ig) play an important role in the immune system both when expressed as
antigen receptors on the cell surface of B cells and as antibodies secreted into extracellular …

The adaptive immune system stores invaluable information about current and past immune
responses and may serve as an ultrasensitive biosensor. Given the immune system's critical …

Early and accurate diagnosis is crucial to prevent disease development and define
therapeutic strategies. Due to predominantly unspecific symptoms, diagnosis of autoimmune …

Antibodies are proteins produced by our immune system that have been harnessed as
biotherapeutics. The discovery of antibody-based therapeutics relies on analyzing large …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19). Variants of concern (VOCs) such as Delta and Omicron have …

Sparked by the development of genome sequencing technology, the quantity and quality of
data handled in immunological research have been changing dramatically. Various data …

Germline variations in immunoglobulin genes influence the repertoire of B cell receptors and
antibodies, and such polymorphisms may impact disease susceptibility. However, the …

Due to their shared genetic history, antibodies from the same clonotype often bind to the
same epitope. This knowledge is used in immune repertoire mining, where known binders …

Antibodies are a cornerstone of the immune system, playing a pivotal role in identifying and
neutralizing infections caused by bacteria, viruses, and other pathogens. Understanding …

The extent to which AIRRs differ among and within individuals remains elusive. Via ultra-
deep repertoire sequencing of 22 and 25 tissues in three cynomolgus macaques …