The role of EREG/EGFR pathway in tumor progression

WL Cheng, PH Feng, KY Lee, KY Chen… - International journal of …, 2021 - mdpi.com
Aberrant activation of the epidermal growth factor receptor (EGFR/ERBB1) by erythroblastic
leukemia viral oncogene homolog (ERBB) ligands contributes to various tumor …

Wound repair at a glance

TJ Shaw, P Martin - Journal of cell science, 2009 - journals.biologists.com
This article is part of a Minifocus on collective cell migration. For further reading, please see
related articles: ʻMechanisms of collective cell migration at a glanceʼ by Olga Ilina and …

Human skin wounds: a major and snowballing threat to public health and the economy

CK Sen, GM Gordillo, S Roy, R Kirsner… - Wound repair and …, 2009 - Wiley Online Library
ABSTRACT In the United States, chronic wounds affect 6.5 million patients. An estimated
excess of US 25billionisspentannuallyontreatmentofchro…,anagingpopulationandasharpriseintheincid …

Wound healing essentials: let there be oxygen

CK Sen - Wound repair and regeneration, 2009 - Wiley Online Library
The state of wound oxygenation is a key determinant of healing outcomes. From a
diagnostic standpoint, measurements of wound oxygenation are commonly used to guide …

Macrophage dysfunction impairs resolution of inflammation in the wounds of diabetic mice

S Khanna, S Biswas, Y Shang, E Collard, A Azad… - PloS one, 2010 - journals.plos.org
Background Chronic inflammation is a characteristic feature of diabetic cutaneous wounds.
We sought to delineate novel mechanisms involved in the impairment of resolution of …

Engulfment of apoptotic cells by macrophages: a role of microRNA-21 in the resolution of wound inflammation

A Das, K Ganesh, S Khanna, CK Sen… - The Journal of …, 2014 - journals.aai.org
At an injury site, efficient clearance of apoptotic cells by wound macrophages or
efferocytosis is a prerequisite for the timely resolution of inflammation. Emerging evidence …

Inflammation as a therapeutic target for diabetic neuropathies

R Pop-Busui, L Ang, C Holmes, K Gallagher… - Current diabetes …, 2016 - Springer
Diabetic neuropathies (DNs) are one of the most prevalent chronic complications of diabetes
and a major cause of disability, high mortality, and poor quality of life. Given the complex …

Redox signaling in diabetic wound healing regulates extracellular matrix deposition

B Kunkemoeller, TR Kyriakides - Antioxidants & redox signaling, 2017 - liebertpub.com
Significance: Impaired wound healing is a major complication of diabetes, and can lead to
development of chronic foot ulcers in a significant number of patients. Despite the danger …

The role of transcription-independent damage signals in the initiation of epithelial wound healing

JV Cordeiro, A Jacinto - Nature reviews Molecular cell biology, 2013 - nature.com
Wound healing is an essential biological process that comprises sequential steps aimed at
restoring the architecture and function of damaged cells and tissues. This process begins …

Topical tissue nano-transfection mediates non-viral stroma reprogramming and rescue

D Gallego-Pérez, D Pal, S Ghatak, V Malkoc… - Nature …, 2017 - nature.com
Although cellular therapies represent a promising strategy for a number of conditions,
current approaches face major translational hurdles, including limited cell sources and the …