Lipid nanoparticle-mediated drug delivery to the brain
Lipid nanoparticles (LNPs) have revolutionized the field of drug delivery through their
applications in siRNA delivery to the liver (Onpattro) and their use in the Pfizer-BioNTech …
applications in siRNA delivery to the liver (Onpattro) and their use in the Pfizer-BioNTech …
Targeted protein delivery based on stimuli‐triggered nanomedicine
J Liu, Y Zhou, Q Lyu, X Yao, W Wang - Exploration, 2024 - Wiley Online Library
Protein‐based drugs have shown unique advantages to treat various diseases in recent
years. However, most protein therapeutics in clinical use are limited to extracellular targets …
years. However, most protein therapeutics in clinical use are limited to extracellular targets …
Polymer-mediated protein/peptide therapeutic stabilization: current progress and future directions
RP Sivasankaran, K Snell, G Kunkel, P Georgiou… - Progress in Polymer …, 2024 - Elsevier
Proteins and peptides have played a pivotal role in revolutionizing disease treatment over
the last century. Despite their commercial success, protein therapeutics can be eliminated or …
the last century. Despite their commercial success, protein therapeutics can be eliminated or …
Endolysosomal trap** of therapeutics and endosomal escape strategies
A Ahmad, JM Khan, BA Paray, K Rashid, A Parvez - Drug Discovery Today, 2024 - Elsevier
Internalizing therapeutic molecules or genes into cells and safely delivering them to the
target tissue where they can perform the intended tasks is one of the key characteristics of …
target tissue where they can perform the intended tasks is one of the key characteristics of …
Lipid nanoparticles for enhancing oral bioavailability
A Gangavarapu, LV Tapia-Lopez, B Sarkar… - Nanoscale, 2024 - pubs.rsc.org
In recent studies, lipid nanoparticles have attained attention as drug delivery systems owing
to their preeminent potential in achieving the desired bioavailability of Biopharmaceutics …
to their preeminent potential in achieving the desired bioavailability of Biopharmaceutics …
High‐Precision Synthesis of RNA‐Loaded Lipid Nanoparticles for Biomedical Applications
The recent development of RNA‐based therapeutics in delivering nucleic acids for gene
editing and regulating protein translation has led to the effective treatment of various …
editing and regulating protein translation has led to the effective treatment of various …
Interactions of inhaled liposome with macrophages and neutrophils determine particle biofate and anti-inflammatory effect in acute lung inflammation
Since most current studies have focused on exploring how phagocyte internalization of drug-
loaded nanovesicles by macrophages would affect the function and therapeutic effects of …
loaded nanovesicles by macrophages would affect the function and therapeutic effects of …
Administration methods of lipid-based nanoparticle delivery systems for cancer treatment
Y Lu, X Pan, Q Nie, Z Zhou, X Dai, O Liu - Biomaterials Science, 2023 - pubs.rsc.org
As nano medications have developed in the recent four decades, nano-delivery systems
have been applied in treating various diseases and are especially common in cancer …
have been applied in treating various diseases and are especially common in cancer …
Receptor-targeted dual pH-triggered intracellular protein transfer
M Lyu, M Yazdi, Y Lin, M Höhn… - ACS Biomaterials …, 2022 - ACS Publications
Protein therapeutics are of widespread interest due to their successful performance in the
current pharmaceutical and medical fields, even though their broad applications have been …
current pharmaceutical and medical fields, even though their broad applications have been …
Polymeric nanostructures containing proteins and peptides for pharmaceutical applications
A Vardaxi, M Kafetzi, S Pispas - Polymers, 2022 - mdpi.com
Over the last three decades, proteins and peptides have attracted great interest as drugs of
choice for combating a broad spectrum of diseases, including diabetes mellitus, cancer, and …
choice for combating a broad spectrum of diseases, including diabetes mellitus, cancer, and …