Lipid nanoparticle-mediated drug delivery to the brain

P Khare, SX Edgecomb, CM Hamadani… - Advanced Drug Delivery …, 2023 - Elsevier
Lipid nanoparticles (LNPs) have revolutionized the field of drug delivery through their
applications in siRNA delivery to the liver (Onpattro) and their use in the Pfizer-BioNTech …

Targeted protein delivery based on stimuli‐triggered nanomedicine

J Liu, Y Zhou, Q Lyu, X Yao, W Wang - Exploration, 2024 - Wiley Online Library
Protein‐based drugs have shown unique advantages to treat various diseases in recent
years. However, most protein therapeutics in clinical use are limited to extracellular targets …

Polymer-mediated protein/peptide therapeutic stabilization: current progress and future directions

RP Sivasankaran, K Snell, G Kunkel, P Georgiou… - Progress in Polymer …, 2024 - Elsevier
Proteins and peptides have played a pivotal role in revolutionizing disease treatment over
the last century. Despite their commercial success, protein therapeutics can be eliminated or …

Endolysosomal trap** of therapeutics and endosomal escape strategies

A Ahmad, JM Khan, BA Paray, K Rashid, A Parvez - Drug Discovery Today, 2024 - Elsevier
Internalizing therapeutic molecules or genes into cells and safely delivering them to the
target tissue where they can perform the intended tasks is one of the key characteristics of …

Lipid nanoparticles for enhancing oral bioavailability

A Gangavarapu, LV Tapia-Lopez, B Sarkar… - Nanoscale, 2024 - pubs.rsc.org
In recent studies, lipid nanoparticles have attained attention as drug delivery systems owing
to their preeminent potential in achieving the desired bioavailability of Biopharmaceutics …

High‐Precision Synthesis of RNA‐Loaded Lipid Nanoparticles for Biomedical Applications

H Seo, L Jeon, J Kwon, H Lee - Advanced Healthcare …, 2023 - Wiley Online Library
The recent development of RNA‐based therapeutics in delivering nucleic acids for gene
editing and regulating protein translation has led to the effective treatment of various …

Interactions of inhaled liposome with macrophages and neutrophils determine particle biofate and anti-inflammatory effect in acute lung inflammation

C Liu, Y Liu, L **, Y He, Y Liang, JCW Mak… - … applied materials & …, 2022 - ACS Publications
Since most current studies have focused on exploring how phagocyte internalization of drug-
loaded nanovesicles by macrophages would affect the function and therapeutic effects of …

Administration methods of lipid-based nanoparticle delivery systems for cancer treatment

Y Lu, X Pan, Q Nie, Z Zhou, X Dai, O Liu - Biomaterials Science, 2023 - pubs.rsc.org
As nano medications have developed in the recent four decades, nano-delivery systems
have been applied in treating various diseases and are especially common in cancer …

Receptor-targeted dual pH-triggered intracellular protein transfer

M Lyu, M Yazdi, Y Lin, M Höhn… - ACS Biomaterials …, 2022 - ACS Publications
Protein therapeutics are of widespread interest due to their successful performance in the
current pharmaceutical and medical fields, even though their broad applications have been …

Polymeric nanostructures containing proteins and peptides for pharmaceutical applications

A Vardaxi, M Kafetzi, S Pispas - Polymers, 2022 - mdpi.com
Over the last three decades, proteins and peptides have attracted great interest as drugs of
choice for combating a broad spectrum of diseases, including diabetes mellitus, cancer, and …