Bone tissue is continuously remodeled through the concerted actions of bone cells, which
include bone resorption by osteoclasts and bone formation by osteoblasts, whereas …

The portrait of osteoblasts and osteocytes has been subjected to a revision, since a large
body of evidence is attributing these cells amazing roles both inside and outside the bone …

The connexin family of channel-forming proteins is present in every tissue type in the human
anatomy. Connexins are best known for forming clustered intercellular channels, structurally …

Connexins are ubiquitous channel forming proteins that assemble as plasma membrane
hemichannels and as intercellular gap junction channels that directly connect cells. In the …

Connexins are a family of transmembrane proteins that play a key role in cardiac physiology.
Gap junctional channels put into contact the cytoplasms of connected cardiomyocytes …

Evaluation of the human genome suggests that all members of the connexin family of gap-
junction proteins have now been successfully identified. This large and diverse family of …

Female fertility is determined to a large extent by the quality (developmental competence) of
the oocyte as reflected in its ability to undergo meiosis, be fertilized, and give rise to a …

The idea that the gap junction family of proteins, connexins, are tumour suppressors has
been widely supported through numerous cancer models. However, the paradigm that …

Ion channels have emerged as regulators of developmental processes. In model organisms
and in people with mutations in ion channels, disruption of ion channel function can affect …

Connexins constitute a large family of trans-membrane proteins that allow intercellular
communication and the transfer of ions and small signaling molecules between cells …