Taste receptors in upper airway innate immunity

RM Carey, RJ Lee - Nutrients, 2019 - mdpi.com
Taste receptors, first identified on the tongue, are best known for their role in guiding our
dietary preferences. The expression of taste receptors for umami, sweet, and bitter have …

Airway glucose homeostasis: a new target in the prevention and treatment of pulmonary infection

EH Baker, DL Baines - Chest, 2018 - Elsevier
In health, the glucose concentration of airway surface liquid (ASL) is 0.4 mM, about 12 times
lower than the blood glucose concentration. Airway glucose homeostasis comprises a set of …

Expanded glucose import capability affords Staphylococcus aureus optimized glycolytic flux during infection

NP Vitko, MR Grosser, D Khatri, TR Lance… - MBio, 2016 - Am Soc Microbiol
Acquisition of numerous virulence determinants affords Staphylococcus aureus greater
pathogenicity than other skin-colonizing staphylococci in humans. Additionally, the …

A geroscience perspective on immune resilience and infectious diseases: a potential case for metformin

JN Justice, S Gubbi, AS Kulkarni, JM Bartley… - Geroscience, 2021 - Springer
We are in the midst of the global pandemic. Though acute respiratory coronavirus (SARS-
COV2) that leads to COVID-19 infects people of all ages, severe symptoms and mortality …

Mechanistic insights into the impact of air pollution on pneumococcal pathogenesis and transmission

D Beentjes, RK Shears, N French, DR Neill… - American Journal of …, 2022 - atsjournals.org
Streptococcus pneumoniae (the pneumococcus) is the leading cause of pneumonia and
bacterial meningitis. A number of recent studies indicate an association between the …

[HTML][HTML] Taste receptors in the upper airway

JR Freund, RJ Lee - World journal of otorhinolaryngology-head and neck …, 2018 - Elsevier
Taste receptors were named for their originally-identified expression on the tongue and role
in the sensation of taste (gustation). They are now known to be involved in many …

Metformin prevents the effects of Pseudomonas aeruginosa on airway epithelial tight junctions and restricts hyperglycaemia‐induced bacterial growth

WRA Patkee, G Carr, EH Baker… - Journal of cellular …, 2016 - Wiley Online Library
Lung disease and elevation of blood glucose are associated with increased glucose
concentration in the airway surface liquid (ASL). Raised ASL glucose is associated with …

Insulin signaling via the PI3-kinase/Akt pathway regulates airway glucose uptake and barrier function in a CFTR-dependent manner

SA Molina, HK Moriarty, DT Infield… - … of Physiology-Lung …, 2017 - journals.physiology.org
Cystic fibrosis-related diabetes is the most common comorbidity associated with cystic
fibrosis (CF) and correlates with increased rates of lung function decline. Because glucose is …

Diabetes, insulin resistance, and asthma: a review of potential links

TD Wu - Current Opinion in Pulmonary Medicine, 2021 - journals.lww.com
Develo** evidence suggests that disorders of glucose metabolism may be associated with
worsening asthma. However, these conditions arise within a network of obesity-related …

Characterization of a novel two-component regulatory system, HptRS, the regulator for the hexose phosphate transport system in Staphylococcus aureus

JY Park, JW Kim, BY Moon, J Lee, YJ Fortin… - Infection and …, 2015 - Am Soc Microbiol
Hexose phosphate is an important carbon source within the cytoplasm of host cells.
Bacterial pathogens that invade, survive, and multiply within various host epithelial cells …