Taste receptors in upper airway innate immunity
Taste receptors, first identified on the tongue, are best known for their role in guiding our
dietary preferences. The expression of taste receptors for umami, sweet, and bitter have …
dietary preferences. The expression of taste receptors for umami, sweet, and bitter have …
Airway glucose homeostasis: a new target in the prevention and treatment of pulmonary infection
EH Baker, DL Baines - Chest, 2018 - Elsevier
In health, the glucose concentration of airway surface liquid (ASL) is 0.4 mM, about 12 times
lower than the blood glucose concentration. Airway glucose homeostasis comprises a set of …
lower than the blood glucose concentration. Airway glucose homeostasis comprises a set of …
Expanded glucose import capability affords Staphylococcus aureus optimized glycolytic flux during infection
NP Vitko, MR Grosser, D Khatri, TR Lance… - MBio, 2016 - Am Soc Microbiol
Acquisition of numerous virulence determinants affords Staphylococcus aureus greater
pathogenicity than other skin-colonizing staphylococci in humans. Additionally, the …
pathogenicity than other skin-colonizing staphylococci in humans. Additionally, the …
A geroscience perspective on immune resilience and infectious diseases: a potential case for metformin
We are in the midst of the global pandemic. Though acute respiratory coronavirus (SARS-
COV2) that leads to COVID-19 infects people of all ages, severe symptoms and mortality …
COV2) that leads to COVID-19 infects people of all ages, severe symptoms and mortality …
Mechanistic insights into the impact of air pollution on pneumococcal pathogenesis and transmission
Streptococcus pneumoniae (the pneumococcus) is the leading cause of pneumonia and
bacterial meningitis. A number of recent studies indicate an association between the …
bacterial meningitis. A number of recent studies indicate an association between the …
[HTML][HTML] Taste receptors in the upper airway
JR Freund, RJ Lee - World journal of otorhinolaryngology-head and neck …, 2018 - Elsevier
Taste receptors were named for their originally-identified expression on the tongue and role
in the sensation of taste (gustation). They are now known to be involved in many …
in the sensation of taste (gustation). They are now known to be involved in many …
Metformin prevents the effects of Pseudomonas aeruginosa on airway epithelial tight junctions and restricts hyperglycaemia‐induced bacterial growth
WRA Patkee, G Carr, EH Baker… - Journal of cellular …, 2016 - Wiley Online Library
Lung disease and elevation of blood glucose are associated with increased glucose
concentration in the airway surface liquid (ASL). Raised ASL glucose is associated with …
concentration in the airway surface liquid (ASL). Raised ASL glucose is associated with …
Insulin signaling via the PI3-kinase/Akt pathway regulates airway glucose uptake and barrier function in a CFTR-dependent manner
SA Molina, HK Moriarty, DT Infield… - … of Physiology-Lung …, 2017 - journals.physiology.org
Cystic fibrosis-related diabetes is the most common comorbidity associated with cystic
fibrosis (CF) and correlates with increased rates of lung function decline. Because glucose is …
fibrosis (CF) and correlates with increased rates of lung function decline. Because glucose is …
Diabetes, insulin resistance, and asthma: a review of potential links
TD Wu - Current Opinion in Pulmonary Medicine, 2021 - journals.lww.com
Develo** evidence suggests that disorders of glucose metabolism may be associated with
worsening asthma. However, these conditions arise within a network of obesity-related …
worsening asthma. However, these conditions arise within a network of obesity-related …
Characterization of a novel two-component regulatory system, HptRS, the regulator for the hexose phosphate transport system in Staphylococcus aureus
JY Park, JW Kim, BY Moon, J Lee, YJ Fortin… - Infection and …, 2015 - Am Soc Microbiol
Hexose phosphate is an important carbon source within the cytoplasm of host cells.
Bacterial pathogens that invade, survive, and multiply within various host epithelial cells …
Bacterial pathogens that invade, survive, and multiply within various host epithelial cells …