Drugs that function through covalent bond formation represent a considerable fraction of our
repository of effective medicines but safety concerns and the complexity of develo** …

Fluorescence polarization holds considerable promise for bioanalytical systems because it
allows the detection of selective interactions in real time and a choice of fluorophores, the …

Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a CAG
repeat expansion in the huntingtin gene (HTT). The new insights into HD's cellular and …

Fluorescent dyes attached to kinase inhibitors (KIs) can be used to probe kinases in vitro, in
cells, and in vivo. Ideal characteristics of the dyes vary with their intended applications …

The activation of c-Jun N-terminal kinases (JNKs) plays an important role in physiological
processes including neuronal function, immune activity, and development, and thus, JNKs …

The concept of covalent inhibition of c-Jun N-terminal kinase 3 (JNK3) was successfully
transferred to our well validated pyridinylimidazole scaffold varying several structural …

Registration of fluorescence anisotropy (FA) allows for characterizing the interactions of
ligands with aptamers and other receptors under homogeneous conditions without reagent …

A panel of methods of general suitability for complete structural elucidation of the
stereochemistry of cyclopeptides, depsipeptides and lipopeptides is presented and …

Starting from known p38α mitogen-activated protein kinase (MAPK) inhibitors, a series of
inhibitors of the c-Jun N-terminal kinase (JNK) 3 was obtained. Altering the substitution …

Within the mitogen-activated protein kinase (MAPK) 1 family, the two kinases of c-Jun N-
terminal kinase 3 (JNK3) and p38α MAPK have emerged in the last decades as particularly …