Distinct spatial and temporal roles for Th1, Th2, and Th17 cells in asthma
W Luo, J Hu, W Xu, J Dong - Frontiers in Immunology, 2022 - frontiersin.org
Immune response in the asthmatic respiratory tract is mainly driven by CD4+ T helper (Th)
cells, represented by Th1, Th2, and Th17 cells, especially Th2 cells. Asthma is a …
cells, represented by Th1, Th2, and Th17 cells, especially Th2 cells. Asthma is a …
[HTML][HTML] Rhinovirus infections and their roles in asthma: etiology and exacerbations
Rhinovirus infections can cause wheezing illnesses in all age groups. In preschool children,
rhinovirus infections frequently initiate acute wheezing illnesses. Children who wheeze with …
rhinovirus infections frequently initiate acute wheezing illnesses. Children who wheeze with …
Eosinophil extracellular traps drive asthma progression through neuro-immune signals
Y Lu, Y Huang, J Li, J Huang, L Zhang, J Feng, J Li… - Nature Cell …, 2021 - nature.com
Eosinophilic inflammation is a feature of allergic asthma. Despite mounting evidence
showing that chromatin filaments released from neutrophils mediate various diseases, the …
showing that chromatin filaments released from neutrophils mediate various diseases, the …
[HTML][HTML] Viral infections in allergy and immunology: how allergic inflammation influences viral infections and illness
MR Edwards, K Strong, A Cameron, RP Walton… - Journal of Allergy and …, 2017 - Elsevier
Viral respiratory tract infections are associated with asthma inception in early life and asthma
exacerbations in older children and adults. Although how viruses influence asthma inception …
exacerbations in older children and adults. Although how viruses influence asthma inception …
A microengineered airway lung chip models key features of viral-induced exacerbation of asthma
Viral-induced exacerbation of asthma remains a major cause of hospitalization and
mortality. New human-relevant models of the airways are urgently needed to understand …
mortality. New human-relevant models of the airways are urgently needed to understand …
Advances in non-type 2 severe asthma: from molecular insights to novel treatment strategies
Asthma is a prevalent pulmonary disease that affects more than 300 million people
worldwide and imposes a substantial economic burden. While medication can effectively …
worldwide and imposes a substantial economic burden. While medication can effectively …
Molecular aspects of allergens and allergy
R Valenta, A Karaulov, V Niederberger… - Advances in …, 2018 - Elsevier
Immunoglobulin E (IgE)-associated allergy is the most common immune disorder. More than
30% of the population suffer from symptoms of allergy which are often severe, disabling, and …
30% of the population suffer from symptoms of allergy which are often severe, disabling, and …
Emerging paradigms in type 2 immunity
H Hammad, N Debeuf, H Aegerter… - Annual Review of …, 2022 - annualreviews.org
A principal purpose of type 2 immunity was thought to be defense against large parasites,
but it also functions in the restoration of homeostasis, such as toxin clearance following …
but it also functions in the restoration of homeostasis, such as toxin clearance following …
[HTML][HTML] Clinical potential of eosinophil-derived neurotoxin in asthma management
A Malinovschi, N Rydell, T Fujisawa, MP Borres… - The Journal of Allergy …, 2023 - Elsevier
The assessment and management of patients with asthma is challenging because of the
complexity of the underlying inflammatory mechanisms and heterogeneity of their clinical …
complexity of the underlying inflammatory mechanisms and heterogeneity of their clinical …
Mechanism of rhinovirus immunity and asthma
Z Yang, H Mitländer, T Vuorinen, S Finotto - Frontiers in immunology, 2021 - frontiersin.org
The majority of asthma exacerbations in children are caused by Rhinovirus (RV), a positive
sense single stranded RNA virus of the Picornavirus family. The host has developed virus …
sense single stranded RNA virus of the Picornavirus family. The host has developed virus …