The physiology, pathology, and pharmacology of voltage-gated calcium channels and their future therapeutic potential
Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …
review, the different subtypes of voltage-gated calcium channels are described and their …
Targeting voltage-gated calcium channels in neurological and psychiatric diseases
GW Zamponi - Nature reviews Drug discovery, 2016 - nature.com
Voltage-gated calcium channels are important regulators of brain, heart and muscle
functions, and their dysfunction can give rise to pathophysiological conditions ranging from …
functions, and their dysfunction can give rise to pathophysiological conditions ranging from …
L-Type CaV1.2 Calcium Channels: From In Vitro Findings to In Vivo Function
F Hofmann, V Flockerzi, S Kahl… - Physiological …, 2014 - journals.physiology.org
The L-type Cav1. 2 calcium channel is present throughout the animal kingdom and is
essential for some aspects of CNS function, cardiac and smooth muscle contractility …
essential for some aspects of CNS function, cardiac and smooth muscle contractility …
[HTML][HTML] Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders
S Heyes, WS Pratt, E Rees, S Dahimene, L Ferron… - Progress in …, 2015 - Elsevier
This review summarises genetic studies in which calcium channel genes have been
connected to the spectrum of neuropsychiatric syndromes, from bipolar disorder and …
connected to the spectrum of neuropsychiatric syndromes, from bipolar disorder and …
CACNA1C (Cav1. 2) in the pathophysiology of psychiatric disease
S Bhat, DT Dao, CE Terrillion, M Arad, RJ Smith… - Progress in …, 2012 - Elsevier
One of the most consistent genetic findings to have emerged from bipolar disorder genome
wide association studies (GWAS) is with CACNA1C, a gene that codes for the α1C subunit …
wide association studies (GWAS) is with CACNA1C, a gene that codes for the α1C subunit …
L‐type Ca2+ channels in heart and brain
J Striessnig, A **gera, G Kaur… - Wiley Interdisciplinary …, 2014 - Wiley Online Library
L‐type calcium channels (Cav1) represent one of the three major classes (Cav1–3) of
voltage‐gated calcium channels. They were identified as the target of clinically used calcium …
voltage‐gated calcium channels. They were identified as the target of clinically used calcium …
Cross-disorder risk gene CACNA1C differentially modulates susceptibility to psychiatric disorders during development and adulthood
Single-nucleotide polymorphisms (SNPs) in CACNA1C, the α1C subunit of the voltage-
gated L-type calcium channel Ca v 1.2, rank among the most consistent and replicable …
gated L-type calcium channel Ca v 1.2, rank among the most consistent and replicable …
Genetic associations between voltage-gated calcium channels and psychiatric disorders
Psychiatric disorders are mental, behavioral or emotional disorders. These conditions are
prevalent, one in four adults suffer from any type of psychiatric disorders world-wide. It has …
prevalent, one in four adults suffer from any type of psychiatric disorders world-wide. It has …
[HTML][HTML] CACNA1D de novo mutations in autism spectrum disorders activate Cav1. 3 L-type calcium channels
A **gera, A Lieb, B Benedetti, M Lampert… - Biological …, 2015 - Elsevier
Abstract Background Cav1. 3 voltage-gated L-type calcium channels (LTCCs) are part of
postsynaptic neuronal signaling networks. They play a key role in brain function, including …
postsynaptic neuronal signaling networks. They play a key role in brain function, including …
[HTML][HTML] Characterization of a human-specific tandem repeat associated with bipolar disorder and schizophrenia
Bipolar disorder (BD) and schizophrenia (SCZ) are highly heritable diseases that affect more
than 3% of individuals worldwide. Genome-wide association studies have strongly and …
than 3% of individuals worldwide. Genome-wide association studies have strongly and …